A Case Report of Kearns-Sayre Syndrome: Not an Absolute Contraindication for Radiotherapy

Kearns-Sayre syndrome (KSS) is a rare mitochondrial disorder, and the effects of radiotherapy on such a population group are unknown. A 60-year-old male with a history of KSS was diagnosed with locally advanced basal cell carcinoma along the left inner canthus. He was treated at our institution with...

Full description

Saved in:
Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-07, Vol.15 (7)
Main Authors: Yap, Shaun Z, Mohd Tahir, Abdul Rahim, Shakespeare, Thomas P
Format: Article
Language:English
Subjects:
Biopsy
Cancer
Case reports
Contraindications
Dermatitis
Exocrine glands
Genetics
Medical imaging
Mitochondrial DNA
Pacemakers
Radiation Oncology
Radiation therapy
Skin cancer
Squamous cell carcinoma
Tomography
Toxicity
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c244t-857ded0b37a90efc876b000f58bb860a0639fbe1de4dca46e8957d4e5fa7a6313
container_end_page
container_issue 7
container_start_page
container_title Curēus (Palo Alto, CA)
container_volume 15
creator Yap, Shaun Z
Mohd Tahir, Abdul Rahim
Shakespeare, Thomas P
description Kearns-Sayre syndrome (KSS) is a rare mitochondrial disorder, and the effects of radiotherapy on such a population group are unknown. A 60-year-old male with a history of KSS was diagnosed with locally advanced basal cell carcinoma along the left inner canthus. He was treated at our institution with curative intent radiotherapy alone and tolerated it well with no major acute or late toxicities. There was a complete clinical and radiological response of the tumor, with no evidence of recurrence 2.5 years after treatment. Further research is needed to explore the effects of ionizing radiation on patients with mitochondrial DNA defects.
doi_str_mv 10.7759/cureus.42229
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10440007</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2859474742</sourcerecordid><originalsourceid>FETCH-LOGICAL-c244t-857ded0b37a90efc876b000f58bb860a0639fbe1de4dca46e8957d4e5fa7a6313</originalsourceid><addsrcrecordid>eNpVUV1LwzAUDaLgmHvzBwR8tTNp0yb1RUbxC4fCpg8-hbS9cR1bUpNU6L-3c0OU-3AvnHPPOXAQOqdkynmaX1Wdg85PWRzH-REaxTQTkaCCHf-5T9HE-zUhhBIeE05G6H2GC-UBL6C1LmCr8RMoZ3y0VL0DvOxN7ewWrvGzDVgZPCu93XQBcGFNcKoxdVOp0FiDtXV4oerGhhU41fZn6ESrjYfJYY_R293ta_EQzV_uH4vZPKpixkIkUl5DTcqEq5yArgTPyiGgTkVZiowokiW5LoHWwOpKsQxEPnwwSLXiKktoMkY3e922K7dQV7DLtZGta7bK9dKqRv5HTLOSH_ZLUsLY4MQHhYuDgrOfHfgg17ZzZggtY5HmjA8TD6zLPaty1nsH-teCErlrQO4bkD8NJN-zqnwI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2859474742</pqid></control><display><type>article</type><title>A Case Report of Kearns-Sayre Syndrome: Not an Absolute Contraindication for Radiotherapy</title><source>Open Access: PubMed Central</source><source>Publicly Available Content (ProQuest)</source><creator>Yap, Shaun Z ; Mohd Tahir, Abdul Rahim ; Shakespeare, Thomas P</creator><creatorcontrib>Yap, Shaun Z ; Mohd Tahir, Abdul Rahim ; Shakespeare, Thomas P</creatorcontrib><description>Kearns-Sayre syndrome (KSS) is a rare mitochondrial disorder, and the effects of radiotherapy on such a population group are unknown. A 60-year-old male with a history of KSS was diagnosed with locally advanced basal cell carcinoma along the left inner canthus. He was treated at our institution with curative intent radiotherapy alone and tolerated it well with no major acute or late toxicities. There was a complete clinical and radiological response of the tumor, with no evidence of recurrence 2.5 years after treatment. Further research is needed to explore the effects of ionizing radiation on patients with mitochondrial DNA defects.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.42229</identifier><language>eng</language><publisher>Palo Alto: Cureus Inc</publisher><subject>Biopsy ; Cancer ; Case reports ; Contraindications ; Dermatitis ; Exocrine glands ; Genetics ; Medical imaging ; Mitochondrial DNA ; Pacemakers ; Radiation Oncology ; Radiation therapy ; Skin cancer ; Squamous cell carcinoma ; Tomography ; Toxicity</subject><ispartof>Curēus (Palo Alto, CA), 2023-07, Vol.15 (7)</ispartof><rights>Copyright © 2023, Yap et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Yap et al. 2023 Yap et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c244t-857ded0b37a90efc876b000f58bb860a0639fbe1de4dca46e8957d4e5fa7a6313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2859474742/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2859474742?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,44569,53769,53771,74872</link.rule.ids></links><search><creatorcontrib>Yap, Shaun Z</creatorcontrib><creatorcontrib>Mohd Tahir, Abdul Rahim</creatorcontrib><creatorcontrib>Shakespeare, Thomas P</creatorcontrib><title>A Case Report of Kearns-Sayre Syndrome: Not an Absolute Contraindication for Radiotherapy</title><title>Curēus (Palo Alto, CA)</title><description>Kearns-Sayre syndrome (KSS) is a rare mitochondrial disorder, and the effects of radiotherapy on such a population group are unknown. A 60-year-old male with a history of KSS was diagnosed with locally advanced basal cell carcinoma along the left inner canthus. He was treated at our institution with curative intent radiotherapy alone and tolerated it well with no major acute or late toxicities. There was a complete clinical and radiological response of the tumor, with no evidence of recurrence 2.5 years after treatment. Further research is needed to explore the effects of ionizing radiation on patients with mitochondrial DNA defects.</description><subject>Biopsy</subject><subject>Cancer</subject><subject>Case reports</subject><subject>Contraindications</subject><subject>Dermatitis</subject><subject>Exocrine glands</subject><subject>Genetics</subject><subject>Medical imaging</subject><subject>Mitochondrial DNA</subject><subject>Pacemakers</subject><subject>Radiation Oncology</subject><subject>Radiation therapy</subject><subject>Skin cancer</subject><subject>Squamous cell carcinoma</subject><subject>Tomography</subject><subject>Toxicity</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpVUV1LwzAUDaLgmHvzBwR8tTNp0yb1RUbxC4fCpg8-hbS9cR1bUpNU6L-3c0OU-3AvnHPPOXAQOqdkynmaX1Wdg85PWRzH-REaxTQTkaCCHf-5T9HE-zUhhBIeE05G6H2GC-UBL6C1LmCr8RMoZ3y0VL0DvOxN7ewWrvGzDVgZPCu93XQBcGFNcKoxdVOp0FiDtXV4oerGhhU41fZn6ESrjYfJYY_R293ta_EQzV_uH4vZPKpixkIkUl5DTcqEq5yArgTPyiGgTkVZiowokiW5LoHWwOpKsQxEPnwwSLXiKktoMkY3e922K7dQV7DLtZGta7bK9dKqRv5HTLOSH_ZLUsLY4MQHhYuDgrOfHfgg17ZzZggtY5HmjA8TD6zLPaty1nsH-teCErlrQO4bkD8NJN-zqnwI</recordid><startdate>20230721</startdate><enddate>20230721</enddate><creator>Yap, Shaun Z</creator><creator>Mohd Tahir, Abdul Rahim</creator><creator>Shakespeare, Thomas P</creator><general>Cureus Inc</general><general>Cureus</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope></search><sort><creationdate>20230721</creationdate><title>A Case Report of Kearns-Sayre Syndrome: Not an Absolute Contraindication for Radiotherapy</title><author>Yap, Shaun Z ; Mohd Tahir, Abdul Rahim ; Shakespeare, Thomas P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c244t-857ded0b37a90efc876b000f58bb860a0639fbe1de4dca46e8957d4e5fa7a6313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biopsy</topic><topic>Cancer</topic><topic>Case reports</topic><topic>Contraindications</topic><topic>Dermatitis</topic><topic>Exocrine glands</topic><topic>Genetics</topic><topic>Medical imaging</topic><topic>Mitochondrial DNA</topic><topic>Pacemakers</topic><topic>Radiation Oncology</topic><topic>Radiation therapy</topic><topic>Skin cancer</topic><topic>Squamous cell carcinoma</topic><topic>Tomography</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yap, Shaun Z</creatorcontrib><creatorcontrib>Mohd Tahir, Abdul Rahim</creatorcontrib><creatorcontrib>Shakespeare, Thomas P</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yap, Shaun Z</au><au>Mohd Tahir, Abdul Rahim</au><au>Shakespeare, Thomas P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Case Report of Kearns-Sayre Syndrome: Not an Absolute Contraindication for Radiotherapy</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><date>2023-07-21</date><risdate>2023</risdate><volume>15</volume><issue>7</issue><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Kearns-Sayre syndrome (KSS) is a rare mitochondrial disorder, and the effects of radiotherapy on such a population group are unknown. A 60-year-old male with a history of KSS was diagnosed with locally advanced basal cell carcinoma along the left inner canthus. He was treated at our institution with curative intent radiotherapy alone and tolerated it well with no major acute or late toxicities. There was a complete clinical and radiological response of the tumor, with no evidence of recurrence 2.5 years after treatment. Further research is needed to explore the effects of ionizing radiation on patients with mitochondrial DNA defects.</abstract><cop>Palo Alto</cop><pub>Cureus Inc</pub><doi>10.7759/cureus.42229</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2168-8184
ispartof Curēus (Palo Alto, CA), 2023-07, Vol.15 (7)
issn 2168-8184
2168-8184
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10440007
source Open Access: PubMed Central; Publicly Available Content (ProQuest)
subjects Biopsy
Cancer
Case reports
Contraindications
Dermatitis
Exocrine glands
Genetics
Medical imaging
Mitochondrial DNA
Pacemakers
Radiation Oncology
Radiation therapy
Skin cancer
Squamous cell carcinoma
Tomography
Toxicity
title A Case Report of Kearns-Sayre Syndrome: Not an Absolute Contraindication for Radiotherapy
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T23%3A50%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Case%20Report%20of%20Kearns-Sayre%20Syndrome:%20Not%20an%20Absolute%20Contraindication%20for%20Radiotherapy&rft.jtitle=Cur%C4%93us%20(Palo%20Alto,%20CA)&rft.au=Yap,%20Shaun%20Z&rft.date=2023-07-21&rft.volume=15&rft.issue=7&rft.issn=2168-8184&rft.eissn=2168-8184&rft_id=info:doi/10.7759/cureus.42229&rft_dat=%3Cproquest_pubme%3E2859474742%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c244t-857ded0b37a90efc876b000f58bb860a0639fbe1de4dca46e8957d4e5fa7a6313%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2859474742&rft_id=info:pmid/&rfr_iscdi=true