Radiologic-Pathologic Correlation of COVID-19-Associated Acute Disseminated Encephalomyelitis

A 42-year-old woman presented with drooling, slurred speech, inability to walk and talk, and a recent positive COVID-19 test. She had two prior hospital admissions within the past week for similar symptoms with inconclusive evaluation. MRI of the brain demonstrated multifocal white matter hyperinten...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-07, Vol.15 (7)
Main Authors: Bezold, Amy, Hussain, Huda, Nwanze, Julum, Roberts, James T, Hsieh, Kuang-chun J
Format: Article
Language:English
Subjects:
Biopsy
Consciousness
Coronaviruses
COVID-19 vaccines
Disease
Encephalomyelitis
Fever
Headaches
Hospitals
Immunization
Infections
Infectious Disease
Magnetic resonance imaging
Middle East respiratory syndrome
Nervous system
Pathology
Patients
Pediatrics
Radiology
Severe acute respiratory syndrome
Steroids
Taste disorders
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Summary:A 42-year-old woman presented with drooling, slurred speech, inability to walk and talk, and a recent positive COVID-19 test. She had two prior hospital admissions within the past week for similar symptoms with inconclusive evaluation. MRI of the brain demonstrated multifocal white matter hyperintense lesions on fluid-attenuated inversion recovery (FLAIR)/diffusion with variable enhancement. These imaging findings have been described in recent literature and are associated with inflammatory demyelinating disease, such as acute disseminated encephalomyelitis. The patient subsequently underwent a brain biopsy with a final diagnosis of inflammatory demyelinating lesion. To our knowledge, this is the first radiologic-pathologic correlation of COVID-19-associated acute disseminated encephalomyelitis.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.42275