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Genetic variation in ZmWAX2 confers maize resistance to Fusarium verticillioides
Summary Fusarium verticillioides (F. verticillioides) is a widely distributed phytopathogen that incites multiple destructive diseases in maize, posing a grave threat to corn yields and quality worldwide. However, there are few reports of resistance genes to F. verticillioides. Here, we reveal that...
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| Published in: | Plant biotechnology journal 2023-09, Vol.21 (9), p.1812-1826 |
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| cites | cdi_FETCH-LOGICAL-c4843-c44e0a904d199c436190af7cbd6ff012ab86bb78c83e54434ee641555e492b7e3 |
| container_end_page | 1826 |
| container_issue | 9 |
| container_start_page | 1812 |
| container_title | Plant biotechnology journal |
| container_volume | 21 |
| creator | Ma, Peipei Liu, Enpeng Zhang, Zhirui Li, Tao Zhou, Zijian Yao, Wen Chen, Jiafa Wu, Jianyu Xu, Yufang Zhang, Huiyong |
| description | Summary
Fusarium verticillioides (F. verticillioides) is a widely distributed phytopathogen that incites multiple destructive diseases in maize, posing a grave threat to corn yields and quality worldwide. However, there are few reports of resistance genes to F. verticillioides. Here, we reveal that a combination of two single nucleotide polymorphisms (SNPs) corresponding to ZmWAX2 gene associates with quantitative resistance variations to F. verticillioides in maize through a genome‐wide association study. A lack of ZmWAX2 compromises maize resistance to F. verticillioides‐caused seed rot, seedling blight and stalk rot by reducing cuticular wax deposition, while the transgenic plants overexpressing ZmWAX2 show significantly increased immunity to F. verticillioides. A natural occurrence of two 7‐bp deletions within the promoter increases ZmWAX2 transcription, thus enhancing maize resistance to F. verticillioides. Upon Fusarium stalk rot, ZmWAX2 greatly promotes the yield and grain quality of maize. Our studies demonstrate that ZmWAX2 confers multiple disease resistances caused by F. verticillioides and can serve as an important gene target for the development of F. verticillioides‐resistant maize varieties. |
| doi_str_mv | 10.1111/pbi.14093 |
| format | article |
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Fusarium verticillioides (F. verticillioides) is a widely distributed phytopathogen that incites multiple destructive diseases in maize, posing a grave threat to corn yields and quality worldwide. However, there are few reports of resistance genes to F. verticillioides. Here, we reveal that a combination of two single nucleotide polymorphisms (SNPs) corresponding to ZmWAX2 gene associates with quantitative resistance variations to F. verticillioides in maize through a genome‐wide association study. A lack of ZmWAX2 compromises maize resistance to F. verticillioides‐caused seed rot, seedling blight and stalk rot by reducing cuticular wax deposition, while the transgenic plants overexpressing ZmWAX2 show significantly increased immunity to F. verticillioides. A natural occurrence of two 7‐bp deletions within the promoter increases ZmWAX2 transcription, thus enhancing maize resistance to F. verticillioides. Upon Fusarium stalk rot, ZmWAX2 greatly promotes the yield and grain quality of maize. Our studies demonstrate that ZmWAX2 confers multiple disease resistances caused by F. verticillioides and can serve as an important gene target for the development of F. verticillioides‐resistant maize varieties.</description><identifier>ISSN: 1467-7644</identifier><identifier>EISSN: 1467-7652</identifier><identifier>DOI: 10.1111/pbi.14093</identifier><identifier>PMID: 37293701</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Biosynthesis ; Blight ; Corn ; Crop yield ; Cuticular wax ; Disease ; disease resistance ; Epicuticular wax ; Fatty acids ; Fusarium ; Fusarium verticillioides ; Genes ; Genetic diversity ; Genome-wide association studies ; Genomes ; Haplotypes ; Infections ; maize (Zea mays L.) ; Nucleotides ; Pathogens ; Seed rot ; Seedling blight ; Seedlings ; Seeds ; Single-nucleotide polymorphism ; Stalk rot ; Transgenic plants ; Waxes ; ZmWAX2</subject><ispartof>Plant biotechnology journal, 2023-09, Vol.21 (9), p.1812-1826</ispartof><rights>2023 The Authors. published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.</rights><rights>2023 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.</rights><rights>2023. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4843-c44e0a904d199c436190af7cbd6ff012ab86bb78c83e54434ee641555e492b7e3</citedby><cites>FETCH-LOGICAL-c4843-c44e0a904d199c436190af7cbd6ff012ab86bb78c83e54434ee641555e492b7e3</cites><orcidid>0000-0002-0487-8609 ; 0000-0002-0777-6034 ; 0000-0002-0643-506X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2853769776/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2853769776?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11553,25744,27915,27916,37003,37004,44581,46043,46467,53782,53784,74887</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37293701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Peipei</creatorcontrib><creatorcontrib>Liu, Enpeng</creatorcontrib><creatorcontrib>Zhang, Zhirui</creatorcontrib><creatorcontrib>Li, Tao</creatorcontrib><creatorcontrib>Zhou, Zijian</creatorcontrib><creatorcontrib>Yao, Wen</creatorcontrib><creatorcontrib>Chen, Jiafa</creatorcontrib><creatorcontrib>Wu, Jianyu</creatorcontrib><creatorcontrib>Xu, Yufang</creatorcontrib><creatorcontrib>Zhang, Huiyong</creatorcontrib><title>Genetic variation in ZmWAX2 confers maize resistance to Fusarium verticillioides</title><title>Plant biotechnology journal</title><addtitle>Plant Biotechnol J</addtitle><description>Summary
Fusarium verticillioides (F. verticillioides) is a widely distributed phytopathogen that incites multiple destructive diseases in maize, posing a grave threat to corn yields and quality worldwide. However, there are few reports of resistance genes to F. verticillioides. Here, we reveal that a combination of two single nucleotide polymorphisms (SNPs) corresponding to ZmWAX2 gene associates with quantitative resistance variations to F. verticillioides in maize through a genome‐wide association study. A lack of ZmWAX2 compromises maize resistance to F. verticillioides‐caused seed rot, seedling blight and stalk rot by reducing cuticular wax deposition, while the transgenic plants overexpressing ZmWAX2 show significantly increased immunity to F. verticillioides. A natural occurrence of two 7‐bp deletions within the promoter increases ZmWAX2 transcription, thus enhancing maize resistance to F. verticillioides. Upon Fusarium stalk rot, ZmWAX2 greatly promotes the yield and grain quality of maize. Our studies demonstrate that ZmWAX2 confers multiple disease resistances caused by F. verticillioides and can serve as an important gene target for the development of F. verticillioides‐resistant maize varieties.</description><subject>Biosynthesis</subject><subject>Blight</subject><subject>Corn</subject><subject>Crop yield</subject><subject>Cuticular wax</subject><subject>Disease</subject><subject>disease resistance</subject><subject>Epicuticular wax</subject><subject>Fatty acids</subject><subject>Fusarium</subject><subject>Fusarium verticillioides</subject><subject>Genes</subject><subject>Genetic diversity</subject><subject>Genome-wide association studies</subject><subject>Genomes</subject><subject>Haplotypes</subject><subject>Infections</subject><subject>maize (Zea mays L.)</subject><subject>Nucleotides</subject><subject>Pathogens</subject><subject>Seed rot</subject><subject>Seedling blight</subject><subject>Seedlings</subject><subject>Seeds</subject><subject>Single-nucleotide polymorphism</subject><subject>Stalk rot</subject><subject>Transgenic plants</subject><subject>Waxes</subject><subject>ZmWAX2</subject><issn>1467-7644</issn><issn>1467-7652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><recordid>eNp1kU1LHTEUhkNpqR914R8ogW7q4moyOZNMVsWKXyDooqXFTcjknrGRmeQ2mblFf73Rq5dW6FnkHMhzXt7kJWSXs31e6mDR-n0OTIs3ZJODVDMl6-rtegbYIFs53zJWcVnL92RDqEoLxfgmuTrFgKN3dGmTt6OPgfpAr4cfhz8r6mLoMGU6WH-PNGH2ebTBIR0jPZly2ZgGusRU9n3f--jnmD-Qd53tM-48923y_eT429HZ7OLy9Pzo8GLmoAFRTkBmNYM519qBkFwz2ynXzmXXMV7ZtpFtqxrXCKwBBCBK4HVdI-iqVSi2yZeV7mJqB5w7DGOyvVkkP9h0Z6L15t-b4H-Zm7g0nEH5qkYXhc_PCin-njCPZvDZYd_bgHHKpmoqkMUrPKKfXqG3cUqhvK9QtVBSKyULtbeiXIo5J-zWbjgzj0GZEpR5CqqwH_-2vyZfkinAwQr443u8-7-Sufp6vpJ8AMbLnR4</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Ma, Peipei</creator><creator>Liu, Enpeng</creator><creator>Zhang, Zhirui</creator><creator>Li, Tao</creator><creator>Zhou, Zijian</creator><creator>Yao, Wen</creator><creator>Chen, Jiafa</creator><creator>Wu, Jianyu</creator><creator>Xu, Yufang</creator><creator>Zhang, Huiyong</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>L6V</scope><scope>LK8</scope><scope>M7P</scope><scope>M7S</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0487-8609</orcidid><orcidid>https://orcid.org/0000-0002-0777-6034</orcidid><orcidid>https://orcid.org/0000-0002-0643-506X</orcidid></search><sort><creationdate>202309</creationdate><title>Genetic variation in ZmWAX2 confers maize resistance to Fusarium verticillioides</title><author>Ma, Peipei ; 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Fusarium verticillioides (F. verticillioides) is a widely distributed phytopathogen that incites multiple destructive diseases in maize, posing a grave threat to corn yields and quality worldwide. However, there are few reports of resistance genes to F. verticillioides. Here, we reveal that a combination of two single nucleotide polymorphisms (SNPs) corresponding to ZmWAX2 gene associates with quantitative resistance variations to F. verticillioides in maize through a genome‐wide association study. A lack of ZmWAX2 compromises maize resistance to F. verticillioides‐caused seed rot, seedling blight and stalk rot by reducing cuticular wax deposition, while the transgenic plants overexpressing ZmWAX2 show significantly increased immunity to F. verticillioides. A natural occurrence of two 7‐bp deletions within the promoter increases ZmWAX2 transcription, thus enhancing maize resistance to F. verticillioides. Upon Fusarium stalk rot, ZmWAX2 greatly promotes the yield and grain quality of maize. Our studies demonstrate that ZmWAX2 confers multiple disease resistances caused by F. verticillioides and can serve as an important gene target for the development of F. verticillioides‐resistant maize varieties.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>37293701</pmid><doi>10.1111/pbi.14093</doi><tpages>1826</tpages><orcidid>https://orcid.org/0000-0002-0487-8609</orcidid><orcidid>https://orcid.org/0000-0002-0777-6034</orcidid><orcidid>https://orcid.org/0000-0002-0643-506X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Plant biotechnology journal, 2023-09, Vol.21 (9), p.1812-1826 |
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| subjects | Biosynthesis Blight Corn Crop yield Cuticular wax Disease disease resistance Epicuticular wax Fatty acids Fusarium Fusarium verticillioides Genes Genetic diversity Genome-wide association studies Genomes Haplotypes Infections maize (Zea mays L.) Nucleotides Pathogens Seed rot Seedling blight Seedlings Seeds Single-nucleotide polymorphism Stalk rot Transgenic plants Waxes ZmWAX2 |
| title | Genetic variation in ZmWAX2 confers maize resistance to Fusarium verticillioides |
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