The association of genetically determined serum glycine with cardiovascular risk in East Asians

Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians. We conducted a geno...

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Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2021-06, Vol.31 (6), p.1840-1844
Main Authors: Chang, Xuling, Wang, Ling, Guan, Shou Ping, Kennedy, Brian K., Liu, Jianjun, Khor, Chiea-Chuen, Low, Adrian F., Chan, Mark Yan-Yee, Yuan, Jian-Min, Koh, Woon-Puay, Friedlander, Yechiel, Dorajoo, Rajkumar, Heng, Chew-Kiat
Format: Article
Language:English
Subjects:
Asian People - genetics
Biomarkers - blood
Carbamoyl-Phosphate Synthase (Ammonia) - genetics
Cardiovascular risk
Case-Control Studies
China - ethnology
Circulating glycine concentration
Coronary Angiography
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - ethnology
Coronary Artery Disease - genetics
Genetic association
Genetic Predisposition to Disease
Genome-Wide Association Study
Glycine - blood
Heart Disease Risk Factors
Humans
Incidence
Polymorphism, Single Nucleotide
Prognosis
Prospective Studies
Risk Assessment
Singapore - epidemiology
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Summary:Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians. We conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated with incident coronary artery disease (CAD) (711 cases and 1,246 controls), cardiovascular death (1,886 cases and 21,707 controls) and angiographic CAD severity (as determined by the Modified Gensini score, N = 1,138). Our study, a first in East Asians, suggest a protective role of glycine against CAD.
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2021.03.010