Predictors of negative outcomes in hospitalized patients with SARS‑CoV‑2 pneumonia: A retrospective study

The coronavirus disease 2019 (COVID-19) pandemic posed a serious threat to human health worldwide after the first case was identified in December 2019. Specific therapeutic options for COVID-19 are lacking; thus, the treatment of patients infected with severe acute respiratory syndrome coronavirus 2...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2023-09, Vol.26 (3), Article 437
Main Authors: Cristea, Alexandra-Maria, Zaharia, Dragos-Cosmin, Jipa-Duna, Daniela, Dumitrache-Rujinski, Stefan, Parliteanu, Oana Andreea, Bogdan, Alexandru Miron, Toma, Claudia Lucia
Format: Article
Language:English
Subjects:
Age
Bacterial pneumonia
Blood
Blood tests
Cardiovascular disease
Care and treatment
Causes of
Comorbidity
Coronaviruses
COVID-19
Development and progression
Diabetes
Disease transmission
Dyspnea
Epidemics
Hospital patients
Hospitalization
Infections
Kidney diseases
Lymphocytes
Medical examination
Medical imaging
Medical research
Medicine, Experimental
Middle East respiratory syndrome
Mortality
Neutrophils
Oxygen saturation
Oxygen therapy
Patient outcomes
Patients
Pneumonia
Prognosis
Regression analysis
Respiratory diseases
Romania
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Statistical analysis
Variables
Ventilators
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Summary:The coronavirus disease 2019 (COVID-19) pandemic posed a serious threat to human health worldwide after the first case was identified in December 2019. Specific therapeutic options for COVID-19 are lacking; thus, the treatment of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is complex in clinical practice. Despite the development of treatment options and methods to limit the spread of SARS-CoV-2, certain patients experience critical illness and numerous deaths have occurred. Notably, treatment of this disease is complex due to the evolution of viral mutations and variants with different rates of infection. Moreover, specific patient characteristics may be associated with rapid disease progression and poor outcomes. Thus, the present study aimed to identify the specific characteristics of patients who developed poor outcomes, including clinical manifestations, blood samples (blood cell count and coagulation tests) at hospital admission and comorbidities. The present study included a total of 1,813 patients hospitalized with pneumonia and SARS-CoV-2 infection, and mortality rates associated with each patient characteristic were calculated. The characteristics associated with the highest risk of mortality were as follows: Age >90 years (OR, 105; 95% CI, 17.70-2,023.00); oxygen saturation at the time of hospital admission
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2023.12137