Development and Validation of a Spectrofluorimetric Method for the Quantification of Capecitabine in Bulk and Tablets

ObjectivesA new, simple, and affordable spectrofluorimetric method was established for quantification of capecitabine in bulk and in marketed formulations. Materials and MethodsNative fluorescence of capecitabine in 0.1% (w/v) cetrimide was measured at 386 nm after excitation at 313 nm. ResultsA lin...

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Bibliographic Details
Published in:Turkish journal of pharmaceutical sciences 2023-08, Vol.20 (4), p.234-239
Main Authors: NARAPARAJU, Swathi, MUKTI, Ambati, ANUMOLU, Durga Panikumar, CHAGANTI, Soujanya
Format: Article
Language:English
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Summary:ObjectivesA new, simple, and affordable spectrofluorimetric method was established for quantification of capecitabine in bulk and in marketed formulations. Materials and MethodsNative fluorescence of capecitabine in 0.1% (w/v) cetrimide was measured at 386 nm after excitation at 313 nm. ResultsA linear relationship between fluorescence intensity and capecitabine concentration was noticed in 0.2-1.0 μg/mL range. The method was supported by checking several validation parameters as stated using International Conference on Harmonization (ICH) guidelines. The limit of detection (LOD) and quantification (LOQ) values (0.032 and 0.096 μg/mL, respectively) and results of validation parameters demonstrated that the method procedure were sensitive, accurate, precise, and reproducible (% relative standard deviation
ISSN:1304-530X
2148-6247
DOI:10.4274/tjps.galenos.2022.46364