"FMR1" CGG Repeats and Stress Influence Self-Reported Cognitive Functioning in Mothers

Variation in the "FMR1" gene may affect aspects of cognition, such as executive function and memory. Environmental factors, such as stress, may also negatively impact cognitive functioning. Participants included 1,053 mothers of children with and without developmental disabilities. Partici...

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Bibliographic Details
Published in:American journal on intellectual and developmental disabilities 2023-01, Vol.128 (1), p.1-20
Main Authors: Maltman, Nell, DaWalt, Leeann Smith, Hong, Jinkuk, Baker, Mei Wang, Berry-Kravis, Elizabeth M, Brilliant, Murray H, Mailick, Marsha
Format: Article
Language:English
Subjects:
Adult children
Autism
Autism Spectrum Disorders
Child
Child Rearing
Children
Children with disabilities
Cognition
Cognition & reasoning
Cognitive Ability
Cognitive Development
Cognitive functioning
Deoxyribonucleic acid
Developmental Disabilities
Disability
DNA
Environment
Environmental aspects
Environmental Influences
Executive Function
Female
Fragile X Mental Retardation Protein - genetics
Genetic diversity
Genetics
Humans
Influence
Life events
Life stress
Memory
Meta Analysis
Mothers
Mothers - psychology
Mutation
Parental stress
Parents
Parents & parenting
Predictor Variables
Self Report
Stress
Stress Variables
Stress, Psychological - genetics
Trinucleotide Repeat Expansion
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Summary:Variation in the "FMR1" gene may affect aspects of cognition, such as executive function and memory. Environmental factors, such as stress, may also negatively impact cognitive functioning. Participants included 1,053 mothers of children with and without developmental disabilities. Participants completed self-report measures of executive function, memory, and stress (i.e., life events, parenting status), and provided DNA to determine CGG repeat length (ranging from 7 to 192 CGGs). Stress exposure significantly predicted greater self-reported difficulties in executive function and the likelihood of memory problems. Cubic CGG effects independently predicted executive function and memory difficulties, suggesting effects of both genetic variation and environmental stress exposure on cognitive functioning.
ISSN:1944-7515
1944-7558
DOI:10.1352/1944-7558-128.1.1