Small Cell Neuroendocrine Carcinoma of the Vagina: A Rare Presentation

Primary small cell neuroendocrine carcinoma of the vagina is a very rare disease. We present a case study of a 52-year-old female who presented to the hospital with complaints of urinary dribbling, burning micturition, pain, and per vaginal bleeding for three to four months. A firm globular mass of...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-07, Vol.15 (7), p.e42387
Main Authors: Asghar, Asma, Usman, Asma, Sheikh, Ali Zafar, Imran, Honeyia, Siddique, Kashif
Format: Article
Language:English
Subjects:
Abdomen
Biopsy
Bladder
Cancer therapies
Case reports
Cervix
Chemotherapy
Females
Genital cancers
Medical prognosis
Metastasis
Neuroendocrine tumors
Nuclear Medicine
Pathology
Pelvis
Radiation therapy
Radiology
Tomography
Vagina
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Summary:Primary small cell neuroendocrine carcinoma of the vagina is a very rare disease. We present a case study of a 52-year-old female who presented to the hospital with complaints of urinary dribbling, burning micturition, pain, and per vaginal bleeding for three to four months. A firm globular mass of approximately 5-6 cm was felt in the anterior vaginal wall per speculum examination. Diagnosis of small cell neuroendocrine carcinoma was made with tissue biopsy and immunohistochemistry. Diagnostic imaging (MRI, positron emission tomography (PET)-CT) plays a vital role in reaching the diagnosis and understanding the treatment response. The patient received six cycles of chemotherapy with cisplatin and etoposide and radiotherapy, achieving a complete response, with complete regression of the lesion. The patient had no sign of tumor recurrence and locoregional or distant metastases after six months of follow-up. Nowadays, there is no need for surgery in the treatment of vaginal small cell neuroendocrine carcinoma, rather radiotherapy and chemotherapy are the treatment of choice. We report a case of neuroendocrine cancer of the vagina treated at our institution.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.42387