Primary Lymphoepithelial Carcinoma of the Submandibular Gland in A Young Patient: A Case Report

Lymphoepithelial carcinoma (LEC) is a rare entity of malignancy. It has been associated with Epstein-Barr virus (EBV), and in regions where it is endemic, such as Southeast Asia, EBV is typically associated with nasopharyngeal carcinoma. The incidence of such malignancies in the young population is...

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Published in:Indian journal of otolaryngology, and head, and neck surgery and head, and neck surgery, 2023-09, Vol.75 (3), p.2577-2580
Main Authors: Ishak, Azlan Iskandar, Kong, Lai Shau, Yunus, Mohd Razif Md, Bakar, Mohd Zulkiflee Abu
Format: Article
Language:English
Subjects:
Cancer
Case reports
Clinical Report
Epstein-Barr virus
Exocrine glands
Head and Neck Surgery
Medicine
Medicine & Public Health
Oral cancer
Otorhinolaryngology
Throat cancer
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Summary:Lymphoepithelial carcinoma (LEC) is a rare entity of malignancy. It has been associated with Epstein-Barr virus (EBV), and in regions where it is endemic, such as Southeast Asia, EBV is typically associated with nasopharyngeal carcinoma. The incidence of such malignancies in the young population is unusual. Here we report a 17-year-old with a 5-year history of a painless right submandibular mass presenting with a sudden increase in size for one month before surgery. Neck examination revealed a firm right submandibular gland measuring five by five cm, with an irregular surface, non-tender with normal overlying skin. We performed a fine needle aspiration cytology (FNAC), and he underwent computed tomography (CT) scan of the neck. He underwent a right submandibulectomy. Lymph nodes from levels I and II were also removed. The final histopathology was reported as LEC. Following this tissue diagnosis, another follow-up surgery, a modified radical neck dissection, was carried out for locoregional clearance. Postoperatively, he completed chemoradiotherapy treatment and is now on regular follow-up.
ISSN:2231-3796
0973-7707
DOI:10.1007/s12070-023-03663-y