Immune-enhancement effects of Angelica gigas Nakai extracts via MAPK/NF-ƙB signaling pathways in cyclophosphamide-induced immunosuppressed mice

This study investigated the immune-enhancement effects of Angelica gigas Nakai extract (ANE) and its yeast-fermented extract (FAN) in cyclophosphamide (CPP)-induced immunosuppressed mice. Angelica gigas Nakai (AGN) increased the protein level of inducible nitric oxide synthase (iNOS) and the product...

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Bibliographic Details
Published in:Food science and biotechnology 2023-10, Vol.32 (11), p.1573-1584
Main Authors: Jeong, Jeongho, Lim, Mi Kyung, Han, Eun Hye, Lee, Sang Ho, Lee, Soyeon
Format: Article
Language:English
Subjects:
Angelica gigas
Chemistry
Chemistry and Materials Science
Cyclophosphamide
Cytokines
Diet
Dietary supplements
Food Science
Immunity
Immunostimulants
Immunosuppression
MAP kinase
Natural killer cells
NF-κB protein
Nitric oxide
Nitric-oxide synthase
Nutrition
Phosphorylation
Research Article
Signal transduction
Splenocytes
Yeasts
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Summary:This study investigated the immune-enhancement effects of Angelica gigas Nakai extract (ANE) and its yeast-fermented extract (FAN) in cyclophosphamide (CPP)-induced immunosuppressed mice. Angelica gigas Nakai (AGN) increased the protein level of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) and immune-related cytokines in mouse splenocytes. AGN also restored CPP-induced suppression of NK cell activity and splenocyte proliferation. Furthermore, AGN activated the ERK and p38 MAPK/NF-κB signaling pathways in mouse splenocytes via phosphorylation of signaling molecules. These findings indicate that upregulation of cytokines and enzymes may be closely associated with the MAPK/NF-κB signaling pathways. In conclusion, AGN can restore CPP-induced immunosuppression in mice, although there was no significant difference in the immune-enhancing effect between ANE and FAN. It is suggested that AGN might have the potential to enhance immunity as an immunostimulant under immunosuppressed conditions. Therefore, it could be used as an effective agent or a dietary supplement for improving immunity.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-023-01281-6