Untargeted metabolite profiling of serum in rats exposed to pyrraline

Pyrraline, one of advanced glycation end-products, is formed in advanced Maillard reactions. It was reported that the presence of pyrraline was tested to be associated with nephropathy and diabetes. Pyrraline might result in potential health risks because many modern diets are heat processed. In the...

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Bibliographic Details
Published in:Food science and biotechnology 2023-10, Vol.32 (11), p.1541-1549
Main Authors: Hu, Chuanqin, Wang, Jiahui, Qi, Fangyuan, Liu, Yingli, Zhao, Fen, Wang, Jing, Sun, Baoguo
Format: Article
Language:English
Subjects:
Advanced glycosylation end products
Arachidonic acid
Biosynthesis
Chemistry
Chemistry and Materials Science
Diabetes mellitus
Food Science
Glycosylation
Health risks
High performance liquid chromatography
Linolenic acid
Liquid chromatography
Maillard reaction
Mass spectrometry
Mass spectroscopy
Metabolic pathways
Metabolism
Metabolites
Metabolomics
Molecular modelling
Nephropathy
Nutrition
Phenylalanine
Research Article
Tryptophan
Tyrosine
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Summary:Pyrraline, one of advanced glycation end-products, is formed in advanced Maillard reactions. It was reported that the presence of pyrraline was tested to be associated with nephropathy and diabetes. Pyrraline might result in potential health risks because many modern diets are heat processed. In the study, an integrated metabolomics by ultra-high-performance liquid chromatography with mass spectrometry was used to evaluate the effects of pyrraline on metabolism in rats. Thirty-two metabolites were identified as differential metabolites. Linolenic acid metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, arachidonic acid metabolism, tyrosine metabolism and glycerophospholipid metabolism were the main perturbed networks in this pathological process. Differential metabolites and metabolic pathways we found give new insights into studying the toxic molecular mechanisms of pyrraline.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-023-01256-7