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Untargeted metabolite profiling of serum in rats exposed to pyrraline
Pyrraline, one of advanced glycation end-products, is formed in advanced Maillard reactions. It was reported that the presence of pyrraline was tested to be associated with nephropathy and diabetes. Pyrraline might result in potential health risks because many modern diets are heat processed. In the...
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| Published in: | Food science and biotechnology 2023-10, Vol.32 (11), p.1541-1549 |
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| container_end_page | 1549 |
| container_issue | 11 |
| container_start_page | 1541 |
| container_title | Food science and biotechnology |
| container_volume | 32 |
| creator | Hu, Chuanqin Wang, Jiahui Qi, Fangyuan Liu, Yingli Zhao, Fen Wang, Jing Sun, Baoguo |
| description | Pyrraline, one of advanced glycation end-products, is formed in advanced Maillard reactions. It was reported that the presence of pyrraline was tested to be associated with nephropathy and diabetes. Pyrraline might result in potential health risks because many modern diets are heat processed. In the study, an integrated metabolomics by ultra-high-performance liquid chromatography with mass spectrometry was used to evaluate the effects of pyrraline on metabolism in rats. Thirty-two metabolites were identified as differential metabolites. Linolenic acid metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, arachidonic acid metabolism, tyrosine metabolism and glycerophospholipid metabolism were the main perturbed networks in this pathological process. Differential metabolites and metabolic pathways we found give new insights into studying the toxic molecular mechanisms of pyrraline. |
| doi_str_mv | 10.1007/s10068-023-01256-7 |
| format | article |
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Differential metabolites and metabolic pathways we found give new insights into studying the toxic molecular mechanisms of pyrraline.</description><subject>Advanced glycosylation end products</subject><subject>Arachidonic acid</subject><subject>Biosynthesis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Diabetes mellitus</subject><subject>Food Science</subject><subject>Glycosylation</subject><subject>Health risks</subject><subject>High performance liquid chromatography</subject><subject>Linolenic acid</subject><subject>Liquid chromatography</subject><subject>Maillard reaction</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Metabolic pathways</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Molecular modelling</subject><subject>Nephropathy</subject><subject>Nutrition</subject><subject>Phenylalanine</subject><subject>Research Article</subject><subject>Tryptophan</subject><subject>Tyrosine</subject><issn>1226-7708</issn><issn>2092-6456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kUtLxTAQhYMoen38ARdScOOmmqRpk65ExBcIbrzrkDbTa6VtapKK_nvnen0v3CQh8805MxxC9hk9ZpTKk4BnoVLKs5QynhepXCMzTkueFiIv1smMcY6fkqotsh3CI9KMS7FJtjJZZFKJfEYu5kM0fgERbNJDNJXr2gjJ6F3Tdu2wSFyTBPBTn7RD4k0MCbyMLiAdXTK-em-Qgl2y0ZguwN7HvUPmlxf359fp7d3VzfnZbVpniscULKutUJUERYWoSqZyqyqrWJ1VDb4rXkoLwpQsyyk1lbRFYUuuhOKKS2ayHXK60h2nqgdbwxBxAD36tjf-VTvT6t-VoX3QC_esGfqVUjBUOPpQ8O5pghB134Yaus4M4KagucqVoAoNET38gz66yQ-435IqSqm4oEjxFVV7F4KH5msaRvUyJr2KSWNM-j0mLbHp4OceXy2fuSCQrYCApWEB_tv7H9k3nnaeCQ</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Hu, Chuanqin</creator><creator>Wang, Jiahui</creator><creator>Qi, Fangyuan</creator><creator>Liu, Yingli</creator><creator>Zhao, Fen</creator><creator>Wang, Jing</creator><creator>Sun, Baoguo</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20231001</creationdate><title>Untargeted metabolite profiling of serum in rats exposed to pyrraline</title><author>Hu, Chuanqin ; Wang, Jiahui ; Qi, Fangyuan ; Liu, Yingli ; Zhao, Fen ; Wang, Jing ; Sun, Baoguo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-ed1cd48b7e8044b9185d8bd81c3bf85db297de4a913500ab7d66d9284828271a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Advanced glycosylation end products</topic><topic>Arachidonic acid</topic><topic>Biosynthesis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Diabetes mellitus</topic><topic>Food Science</topic><topic>Glycosylation</topic><topic>Health risks</topic><topic>High performance liquid chromatography</topic><topic>Linolenic acid</topic><topic>Liquid chromatography</topic><topic>Maillard reaction</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Metabolic pathways</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metabolomics</topic><topic>Molecular modelling</topic><topic>Nephropathy</topic><topic>Nutrition</topic><topic>Phenylalanine</topic><topic>Research Article</topic><topic>Tryptophan</topic><topic>Tyrosine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Chuanqin</creatorcontrib><creatorcontrib>Wang, Jiahui</creatorcontrib><creatorcontrib>Qi, Fangyuan</creatorcontrib><creatorcontrib>Liu, Yingli</creatorcontrib><creatorcontrib>Zhao, Fen</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Sun, Baoguo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Food science and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Chuanqin</au><au>Wang, Jiahui</au><au>Qi, Fangyuan</au><au>Liu, Yingli</au><au>Zhao, Fen</au><au>Wang, Jing</au><au>Sun, Baoguo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Untargeted metabolite profiling of serum in rats exposed to pyrraline</atitle><jtitle>Food science and biotechnology</jtitle><stitle>Food Sci Biotechnol</stitle><addtitle>Food Sci Biotechnol</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>32</volume><issue>11</issue><spage>1541</spage><epage>1549</epage><pages>1541-1549</pages><issn>1226-7708</issn><eissn>2092-6456</eissn><abstract>Pyrraline, one of advanced glycation end-products, is formed in advanced Maillard reactions. 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| ispartof | Food science and biotechnology, 2023-10, Vol.32 (11), p.1541-1549 |
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| source | Springer Nature; PubMed Central |
| subjects | Advanced glycosylation end products Arachidonic acid Biosynthesis Chemistry Chemistry and Materials Science Diabetes mellitus Food Science Glycosylation Health risks High performance liquid chromatography Linolenic acid Liquid chromatography Maillard reaction Mass spectrometry Mass spectroscopy Metabolic pathways Metabolism Metabolites Metabolomics Molecular modelling Nephropathy Nutrition Phenylalanine Research Article Tryptophan Tyrosine |
| title | Untargeted metabolite profiling of serum in rats exposed to pyrraline |
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