Diagnostic Accuracy of Epilepsy-dedicated MRI with Post-processing

Purpose To evaluate the diagnostic accuracy of epilepsy-dedicated 3 Tesla MRI including post-processing by correlating MRI, histopathology, and postsurgical seizure outcomes. Methods 3 Tesla-MRI including a magnetization-prepared two rapid acquisition gradient echo (MP2RAGE) sequence for post-proces...

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Published in:Clinical neuroradiology (Munich) 2023-09, Vol.33 (3), p.709-719
Main Authors: Urbach, Horst, Scheiwe, Christian, Shah, Muskesh J., Nakagawa, Julia M., Heers, Marcel, San Antonio-Arce, Maria Victoria, Altenmueller, Dirk-Matthias, Schulze-Bonhage, Andreas, Huppertz, Hans-Juergen, Demerath, Theo, Doostkam, Soroush
Format: Article
Language:English
Subjects:
Convulsions & seizures
Drug resistance
Dysplasia
Epilepsy
Histochemistry
Histopathology
Magnetic resonance imaging
Magnetization
Medicine
Medicine & Public Health
Neurology
Neuroradiology
Neurosurgery
Original
Original Article
Sampling error
Seizures (Medicine)
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Summary:Purpose To evaluate the diagnostic accuracy of epilepsy-dedicated 3 Tesla MRI including post-processing by correlating MRI, histopathology, and postsurgical seizure outcomes. Methods 3 Tesla-MRI including a magnetization-prepared two rapid acquisition gradient echo (MP2RAGE) sequence for post-processing using the morphometric analysis program MAP was acquired in 116 consecutive patients with drug-resistant focal epilepsy undergoing resection surgery. The MRI, histopathology reports and postsurgical seizure outcomes were recorded from the patient’s charts. Results The MRI and histopathology were concordant in 101 and discordant in 15 patients, 3 no hippocampal sclerosis/gliosis only lesions were missed on MRI and 1 of 28 focal cortical dysplasia (FCD) type II associated with a glial scar was considered a glial scar only on MRI. In another five patients, MRI was suggestive of FCD, the histopathology was uneventful but patients were seizure-free following surgery. The MRI and histopathology were concordant in 20 of 21 glioneuronal tumors, 6 cavernomas, and 7 glial scars. Histopathology was negative in 10 patients with temporal lobe epilepsy, 4 of them had anteroinferior meningoencephaloceles. Engel class IA outcome was reached in 71% of patients. Conclusion The proposed MRI protocol is highly accurate. No hippocampal sclerosis/gliosis only lesions are typically MRI negative. Small MRI positive FCD can be histopathologically missed, most likely due to sampling errors resulting from insufficient harvesting of tissue.
ISSN:1869-1439
1869-1447
DOI:10.1007/s00062-023-01265-3