Cross-presenting Langerhans cells are required for the early reactivation of resident CD8 + memory T cells in the epidermis

Tissue-resident memory CD8 T cells (T ) reside at sites of previous infection, providing protection against reinfection with the same pathogen. In the skin, T patrol the epidermis, where keratinocytes are the entry site for many viral infections. Epidermal T react rapidly to cognate antigen encounte...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2023-08, Vol.120 (34), p.e2219932120-e2219932120
Main Authors: Kamenjarin, Nadine, Hodapp, Katrin, Melchior, Felix, Harms, Gregory, Hartmann, Ann-Kathrin, Bartneck, Joschka, Muth, Sabine, Raker, Verena K, Becker, Christian, Brand, Anna, Clausen, Björn E, Radsak, Markus P, Schild, Hansjörg, Probst, Hans Christian
Format: Article
Language:English
Subjects:
Antigen-presenting cells
Antigens
Biological Sciences
CD8 antigen
CD8-Positive T-Lymphocytes
Cell differentiation
Cytotoxicity
Effector cells
Epidermis
Humans
Immunologic Memory
Immunological memory
Keratinocytes
Langerhans Cells
Lymphocytes
Lymphocytes T
Memory cells
Memory T Cells
Reinfection - metabolism
Skin
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Summary:Tissue-resident memory CD8 T cells (T ) reside at sites of previous infection, providing protection against reinfection with the same pathogen. In the skin, T patrol the epidermis, where keratinocytes are the entry site for many viral infections. Epidermal T react rapidly to cognate antigen encounter with the secretion of cytokines and differentiation into cytotoxic effector cells, constituting a first line of defense against skin reinfection. Despite the important protective role of skin T , it has remained unclear, whether their reactivation requires a professional antigen-presenting cell (APC). We show here, using a model system that allows antigen targeting selectively to keratinocytes in a defined area of the skin, that limited antigen expression by keratinocytes results in rapid, antigen-specific reactivation of skin T . Our data identify epidermal Langerhans cells that cross-present keratinocyte-derived antigens, as the professional APC indispensable for the early reactivation of T in the epidermal layer of the skin.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.2219932120