A mouse intracerebral infection with Neisseria gonorrhoeae

An intracerebral challenge of HPB black mice with Neisseria gonorrhoeae is described. In this mode, the mice died from 1 to 6 days after challenge, and T1 organisms were obtained up to the fifth day from brain, liver, kidney, and spleen. Experimental gonococcal vaccines gave good protection against...

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Bibliographic Details
Published in:British journal of venereal diseases 1975-02, Vol.51 (1), p.22-24
Main Authors: Diena, B B, Ryan, A, Ashton, F E, Wallace, R, Perry, M B, Daoust, V
Format: Article
Language:English
Subjects:
Animals
Bacterial Vaccines
Brain - immunology
Brain - microbiology
Brain Diseases - microbiology
Disease Models, Animal
Female
Gonorrhea - immunology
Gonorrhea - microbiology
Kidney - microbiology
Lethal Dose 50
Liver - microbiology
Mice
Mice, Inbred Strains
Neisseria gonorrhoeae - immunology
Neisseria gonorrhoeae - isolation & purification
Neisseria gonorrhoeae - pathogenicity
Spleen - microbiology
Vaccination
Vaccines, Attenuated
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Summary:An intracerebral challenge of HPB black mice with Neisseria gonorrhoeae is described. In this mode, the mice died from 1 to 6 days after challenge, and T1 organisms were obtained up to the fifth day from brain, liver, kidney, and spleen. Experimental gonococcal vaccines gave good protection against the challenge.
ISSN:0007-134X
1368-4973
1472-3263
DOI:10.1136/sti.51.1.22