Long-Term Survival Analysis and Prognostic Factors of Arabic Patients with Differentiated Thyroid Carcinoma: A 20-Year Observational Study at the King Hussein Cancer Center (KHCC) Involving 528 Patients

DTC accounts for the majority of endocrine tumors. While the incidence of thyroid cancer has been increasing globally over the past few decades, papillary thyroid carcinoma (PTC) generally shows an excellent prognosis, except in cases with aggressive clinicopathological features. This study aimed to...

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Bibliographic Details
Published in:Cancers 2023-08, Vol.15 (16), p.4102
Main Authors: Al-Ibraheem, Akram, Al-Rasheed, Ula, Mashhadani, Noor, Abdlkadir, Ahmed Saad, Al-Adhami, Dhuha Ali, Ruzzeh, Saad, Istatieh, Feras, Mansour, Areen, Hamdan, Basem, Kheetan, Reem, Al-Shatti, Marwa, Mohamad, Issa, Juweid, Malik E, Abu Sheikha, Areej, Al-Rabi, Kamal, Sykiotis, Gerasimos P, Kreissl, Michael C, Ismael, Taleb, Sultan, Iyad, Abdel-Razeq, Hikmat
Format: Article
Language:English
Subjects:
Analysis
Cancer
Cancer therapies
Carcinoma
Development and progression
Disease control
Gender
Geographical variations
Iodine
Lymphatic system
Males
Medical prognosis
Medical records
Metastases
Metastasis
Mortality
Neck
Observational studies
Oncology
Oncology, Experimental
Papillary thyroid carcinoma
Patient outcomes
Patients
Population studies
Prognosis
Radiation
Survival
Survival analysis
Thyroid cancer
Thyroidectomy
Tomography
Tumors
Ultrasonic imaging
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Summary:DTC accounts for the majority of endocrine tumors. While the incidence of thyroid cancer has been increasing globally over the past few decades, papillary thyroid carcinoma (PTC) generally shows an excellent prognosis, except in cases with aggressive clinicopathological features. This study aimed to assess the 5- and 10-year overall survival (OS) and progression-free survival (PFS) of 528 Arabic patients diagnosed with primary DTC from 1998 to 2021. Additionally, the study aimed to analyze the impact of various factors on both OS and PFS. An univariable survival analysis was conducted using Kaplan–Meier curves. The 5- and 10-year OS for patients with DTC have exceeded 95%. Additionally, PFS showed very good rates (ranging between 96.5 and 85% at 5 and 10 years, respectively). Age, male gender, risk of recurrence, and distant metastasis were identified as the main negative prognostic factors for both OS and PFS, while RAI treatment was found to be a significant factor in improving OS. Moreover, adherence to the King Hussein Cancer Center’s (KHCC) CPG demonstrated significant improvement in PFS. These findings highlight common prognostic factors and favorable outcomes in Arabic patients with DTC treated at a tertiary cancer center using standard of care approaches.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15164102