Neurosyphilis

In patients with abnormal neuropsychiatric symptoms and a reactive fluorescent treponemal antibody absoption (FTA-ABS) test in the cerebrospinal fluid (CSF) or serum, a normal CSF cell count and total protein concentration does not exlude late syphilis involving the central nervous system. In these...

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Bibliographic Details
Published in:British journal of venereal diseases 1977-08, Vol.53 (4), p.221-225
Main Authors: Kolar, O J, Burkhart, J E
Format: Article
Language:English
Subjects:
Adult
Aged
Cerebrospinal Fluid - cytology
Cerebrospinal Fluid Proteins - analysis
Female
Fluorescent Antibody Technique
Humans
Immunoelectrophoresis
Immunoglobulin Fab Fragments - cerebrospinal fluid
Immunoglobulin G - cerebrospinal fluid
Immunoglobulin M - analysis
Male
Middle Aged
Neurosyphilis - diagnosis
Neurosyphilis - immunology
Syphilis Serodiagnosis
Treponema pallidum - immunology
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Description
Summary:In patients with abnormal neuropsychiatric symptoms and a reactive fluorescent treponemal antibody absoption (FTA-ABS) test in the cerebrospinal fluid (CSF) or serum, a normal CSF cell count and total protein concentration does not exlude late syphilis involving the central nervous system. In these patients, the presence of plasma cells in the CSF cytogram, increased concentration of CSF immunoglobulin G (IgG), immunoelectrophoretic abnormalities in the precipitates of the IgG and of the Fab fragments of IgG in the CSF immunoelectropherogram, and an increased serum level of immunoglobulin M (IgM) suggest an active, potentially treatable neurosyphilis.
ISSN:0007-134X
1368-4973
1472-3263
DOI:10.1136/sti.53.4.221