Renal Glucose Release after Unilateral Renal Denervation during a Hypoglycemic Clamp in Pigs with an Altered Hypothalamic Pituitary Adrenal Axis after Late-Gestational Dexamethasone Injection

Previously, we demonstrated in pigs that renal denervation halves glucose release during hypoglycaemia and that a prenatal dexamethasone injection caused increased ACTH and cortisol concentrations as markers of a heightened hypothalamic pituitary adrenal axis (HPAA) during hypoglycaemia. In this stu...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-08, Vol.24 (16), p.12738
Main Authors: Nistor, Marius, Schmidt, Martin, Klingner, Carsten, Klingner, Caroline, Schwab, Matthias, Bischoff, Sabine Juliane, Matziolis, Georg, Rodríguez-González, Guadalupe Leticia, Schiffner, René
Format: Article
Language:English
Subjects:
ACTH
Analysis
Antihypertensives
Blood pressure
Blood sugar
Brain
Central nervous system depressants
Denervation
Dexamethasone
Diabetes
Diabetics
Drug dosages
Glucose
Hogs
Homeostasis
Hormones
Hypertension
Hypoglycemia
Influence
Kidneys
Patients
Physiology
Rankings
Steroids
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Summary:Previously, we demonstrated in pigs that renal denervation halves glucose release during hypoglycaemia and that a prenatal dexamethasone injection caused increased ACTH and cortisol concentrations as markers of a heightened hypothalamic pituitary adrenal axis (HPAA) during hypoglycaemia. In this study, we investigated the influence of an altered HPAA on renal glucose release during hypoglycaemia. Pigs whose mothers had received two late-gestational dexamethasone injections were subjected to a 75 min hyperinsulinaemic–hypoglycaemic clamp (
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241612738