LSS rs2254524 Increases the Risk of Hypertension in Children and Adolescents with Obesity

Childhood obesity and its related comorbidities have become major health issues over the last century. Among these comorbidities, cardiovascular diseases, especially hypertension, are the most significant. Recently, a polymorphism affecting the activity of lanosterol synthase has been associated wit...

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Bibliographic Details
Published in:Genes 2023-08, Vol.14 (8), p.1618
Main Authors: Umano, Giuseppina Rosaria, Cirillo, Grazia, Rondinelli, Giulia, Sanchez, Gianmaria, Marzuillo, Pierluigi, Guarino, Stefano, Di Sessa, Anna, Papparella, Alfonso, Miraglia del Giudice, Emanuele
Format: Article
Language:English
Subjects:
Adolescents
Adults
Age groups
Alleles
Blood pressure
Cardiovascular disease
Cardiovascular diseases
Children
Comorbidity
Confidence intervals
Diabetes
Gene loci
Health risk assessment
Hypertension
Kidney diseases
Lanosterol
Lanosterol synthase
Lifestyles
Metabolic disorders
Metabolic syndrome
MicroRNAs
Obesity
Overweight
Pandemics
Pediatrics
Proteins
Risk factors
Steroids
Teenagers
Weight control
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Summary:Childhood obesity and its related comorbidities have become major health issues over the last century. Among these comorbidities, cardiovascular diseases, especially hypertension, are the most significant. Recently, a polymorphism affecting the activity of lanosterol synthase has been associated with an increased risk of hypertension in adolescents. In this study, we aimed to investigate the effect of LSS rs2254524 polymorphism on blood pressure in children and adolescents with obesity. We enrolled 828 obese children aged 6–17 years. Subjects carrying the A allele showed higher rates of systolic and diastolic stage I hypertension and stage II hypertension. Carriers of the A allele showed a 2.4-fold (95% C.I. 1.5–4.7, p = 0.01) higher risk for stage II hypertension and a 1.9-fold higher risk for stage I hypertension (95% C.I. 1.4–2.6, p < 0.0001). The risk was independent of confounding factors. In conclusion, LSS rs2254524 worsens the cardiovascular health of children and adolescents with obesity, increasing their blood pressure.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes14081618