The Role of Osteopontin in Respiratory Health and Disease

The biological functions of osteopontin (OPN) are diverse and specific to physiological and pathophysiological conditions implicated in inflammation, biomineralization, cardiovascular diseases, cellular viability, cancer, diabetes, and renal stone disease. We aimed to present the role of OPN in resp...

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Bibliographic Details
Published in:Journal of personalized medicine 2023-08, Vol.13 (8), p.1259
Main Authors: Barkas, Georgios I, Kotsiou, Ourania S
Format: Article
Language:English
Subjects:
Asthma
Biomarkers
Cancer
Cardiovascular diseases
Cell viability
Chemotherapy
Chronic obstructive pulmonary disease
Coronavirus infections
Coronaviruses
COVID-19
Cytokines
Development and progression
Diabetes mellitus
Diseases
Extracellular matrix
Glycoproteins
Granuloma
Growth factors
Hyperplasia
Immune system
Inflammation
Kidney stones
Kinases
Leukocytes (eosinophilic)
Leukocytes (neutrophilic)
Lithiasis
Lung cancer
Lung diseases
Lung diseases, Obstructive
Metastases
Metastasis
Mineralization
Nephrolithiasis
Neutrophils
Obstructive lung disease
Osteopontin
Parenchyma
Phenotypes
Physiological aspects
Physiology
Precision medicine
Proteins
Respiratory diseases
Respiratory tract diseases
Review
Roles
Smooth muscle
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Summary:The biological functions of osteopontin (OPN) are diverse and specific to physiological and pathophysiological conditions implicated in inflammation, biomineralization, cardiovascular diseases, cellular viability, cancer, diabetes, and renal stone disease. We aimed to present the role of OPN in respiratory health and disease. OPN influences the immune system and is a chemo-attractive protein correlated with respiratory disease severity. There is evidence that OPN can advance the disease stage associated with its fibrotic, inflammatory, and immune functions. OPN contributes to eosinophilic airway inflammation. OPN can destroy the lung parenchyma through its neutrophil influx and fibrotic mechanisms, linking OPN to at least one of the two major chronic obstructive pulmonary disease phenotypes. Respiratory diseases that involve irreversible lung scarring, such as idiopathic pulmonary disease, are linked to OPN, with protein levels being overexpressed in individuals with severe or advanced stages of the disorders and considerably lower levels in those with less severe symptoms. OPN plays a significant role in lung cancer progression and metastasis. It is also implicated in the pathogenesis of pulmonary hypertension, coronavirus disease 2019, and granuloma generation.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm13081259