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Penicillin concentrations in cerebrospinal fluid after different treatment regimens for syphilis
The concentrations of penicillin in the cerebrospinal fluid (CSF) were compared simultaneously with those in the serum in 17 patients with syphilis. The antibiotic concentrations were measured by the agar well diffusion method. There were no detectable concentrations of penicillin in the CSF after a...
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| Published in: | British journal of venereal diseases 1980-12, Vol.56 (6), p.363-367 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-b511t-bd8f612ea20806be5621df84ef4ea2a1572be1df1f0912355f112f1103566a083 |
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| cites | cdi_FETCH-LOGICAL-b511t-bd8f612ea20806be5621df84ef4ea2a1572be1df1f0912355f112f1103566a083 |
| container_end_page | 367 |
| container_issue | 6 |
| container_start_page | 363 |
| container_title | British journal of venereal diseases |
| container_volume | 56 |
| creator | Polnikorn, N Witoonpanich, R Vorachit, M Vejjajiva, S Vejjajiva, A |
| description | The concentrations of penicillin in the cerebrospinal fluid (CSF) were compared simultaneously with those in the serum in 17 patients with syphilis. The antibiotic concentrations were measured by the agar well diffusion method. There were no detectable concentrations of penicillin in the CSF after administration of benzathine penicillin 2.4 megaunits, benzathine penicillin 7.2 megaunits, procaine penicillin in aluminium monostearate (PAM) 12 megaunits, or aqueous procaine penicillin G 2.4 megaunits. Only after high doses of aqueous penicillin G 24 megaunits daily or aqueous penicillin G 2 megaunits daily together with oral probenecid 2 g daily was penicillin detectable in the CSF. The concentrations after the latter regimen were the highest and much higher than the minimum inhibitory concentration for Treponema pallidum. |
| doi_str_mv | 10.1136/sti.56.6.363 |
| format | article |
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The antibiotic concentrations were measured by the agar well diffusion method. There were no detectable concentrations of penicillin in the CSF after administration of benzathine penicillin 2.4 megaunits, benzathine penicillin 7.2 megaunits, procaine penicillin in aluminium monostearate (PAM) 12 megaunits, or aqueous procaine penicillin G 2.4 megaunits. Only after high doses of aqueous penicillin G 24 megaunits daily or aqueous penicillin G 2 megaunits daily together with oral probenecid 2 g daily was penicillin detectable in the CSF. 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The antibiotic concentrations were measured by the agar well diffusion method. There were no detectable concentrations of penicillin in the CSF after administration of benzathine penicillin 2.4 megaunits, benzathine penicillin 7.2 megaunits, procaine penicillin in aluminium monostearate (PAM) 12 megaunits, or aqueous procaine penicillin G 2.4 megaunits. Only after high doses of aqueous penicillin G 24 megaunits daily or aqueous penicillin G 2 megaunits daily together with oral probenecid 2 g daily was penicillin detectable in the CSF. The concentrations after the latter regimen were the highest and much higher than the minimum inhibitory concentration for Treponema pallidum.</description><subject>Adult</subject><subject>Aged</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Penicillin G - administration & dosage</subject><subject>Penicillin G Benzathine - administration & dosage</subject><subject>Penicillin G Procaine - administration & dosage</subject><subject>Penicillins - cerebrospinal fluid</subject><subject>Probenecid - administration & dosage</subject><subject>Syphilis - cerebrospinal fluid</subject><subject>Syphilis - drug therapy</subject><issn>0007-134X</issn><issn>1368-4973</issn><issn>1472-3263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><recordid>eNp9kc9rFDEUx4Moda3evAoDgl6cbV4yScaLIIvWlmKrVBEvMTOTtNlmkjXJiP3vm2WWRT14CHm874f364vQU8BLAMqPUrZLxpd8STm9hxbQCFJTwul9tMAYixpo8-0hepTSGmMOLREH6EA0TctEu0A_LrS3vXXO-qoPvtc-R5Vt8KnaZnTUXQxpY71ylXGTHSplso7VYI0pos9VjlrlcRtFfWVLkCoTYpVuN9fW2fQYPTDKJf1k9x-iL-_fXa4-1Gfnxyert2d1xwBy3Q2t4UC0IrjFvNOMExhM22jTlJwCJkinSwYMfg2EMmYASHmYMs4VbukhejPX3UzdqId5ESc30Y4q3sqgrPxb8fZaXoVfEnDDWkpKgRe7AjH8nHTKcrSp184pr8OUpGAN5oxvOz3_B1yHKZYDJQlCAOaYMVGoVzPVl_ulqM1-FMBy65ssvknGJZfFt4I_-3P8Pbwzquj1rNuU9e-9rOKN5IIKJj9-XclT-PT94vL0WH4u_MuZ78b1_zvfAV4Isig</recordid><startdate>19801201</startdate><enddate>19801201</enddate><creator>Polnikorn, N</creator><creator>Witoonpanich, R</creator><creator>Vorachit, M</creator><creator>Vejjajiva, S</creator><creator>Vejjajiva, A</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19801201</creationdate><title>Penicillin concentrations in cerebrospinal fluid after different treatment regimens for syphilis</title><author>Polnikorn, N ; 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| fulltext | fulltext |
| identifier | ISSN: 0007-134X |
| ispartof | British journal of venereal diseases, 1980-12, Vol.56 (6), p.363-367 |
| issn | 0007-134X 1368-4973 1472-3263 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1045832 |
| source | PubMed Central |
| subjects | Adult Aged Drug Therapy, Combination Female Humans Male Middle Aged Penicillin G - administration & dosage Penicillin G Benzathine - administration & dosage Penicillin G Procaine - administration & dosage Penicillins - cerebrospinal fluid Probenecid - administration & dosage Syphilis - cerebrospinal fluid Syphilis - drug therapy |
| title | Penicillin concentrations in cerebrospinal fluid after different treatment regimens for syphilis |
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