Demyelinating Inflammatory Disorders of the Central Nervous System in the Era of COVID-19: Cases with Mild Infectious Symptoms

A polymerase chain reaction (PCR) panel of CSF for SARS-CoV-2, herpes simplex 1 and 2, Haemophilus influenzae, Mycobacterium tuberculosis and Listeria monocytogenes, as well as CSF, blood and urine cultures were negative. The patient was diagnosed with seronegative NMOSD, on the basis of the presenc...

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Bibliographic Details
Published in:Noro-Psikiyatri Arsivi 2023-09, Vol.60 (3), p.191-193
Main Authors: Ozkan Yasargun, Duygu, Turkoglu, Recai, Tuzun, Erdem
Format: Article
Language:English
Subjects:
Acute respiratory distress syndrome
Antibodies
Asymptomatic
Case studies
Central nervous system
Consciousness
Coronaviruses
COVID-19
Demyelinating diseases
Health aspects
Infection
Infections
Inflammatory diseases
Medical research
Muscle strength
Nervous system
Neurologic manifestations of general diseases
Neurophysiology
Olfaction disorders
Patients
Pneumonia
Polymerase chain reaction
Risk factors
Severe acute respiratory syndrome coronavirus 2
Spinal cord
Viral infections
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Summary:A polymerase chain reaction (PCR) panel of CSF for SARS-CoV-2, herpes simplex 1 and 2, Haemophilus influenzae, Mycobacterium tuberculosis and Listeria monocytogenes, as well as CSF, blood and urine cultures were negative. The patient was diagnosed with seronegative NMOSD, on the basis of the presence of two core clinical characteristics of acute myelitis with longitudinally extensive transverse myelitis (LETM) and area postrema syndrome, dissemination in space (spinal cord, brainstem and cerebellum) and neuroimaging features associated with the core clinical findings (spinal cord and medulla lesions on MRI) (8). Viral infections are well known to induce an inflammatory response against the CNS, to activate myelin-specific T cells and by this way to accelerate the development of early or delayed virus-induced demyelination (16). Author Contributions: Concept- RT; Design- DÖY.; Supervision- ET; Resource- DÖY; Materials- (-); Data Collection and/or Processing- RT; Analysis and/or InterpretationDÖY; Literature Search- DÖY; Writing- DÖY; Critical Reviews- ET.
ISSN:1300-0667
1309-4866
DOI:10.29399/npa.28525