Rosoxacin in the treatment of uncomplicated gonorrhoea in men

Between 3 January and 4 March 1983 we treated 200 male patients diagnosed as having uncomplicated gonococcal urethritis with one of two regimens. They were divided into two groups and randomly assigned to treatment with either 2 g spectinomycin administered intramuscularly (group A) or 300 mg rosoxa...

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Bibliographic Details
Published in:British journal of venereal diseases 1984-08, Vol.60 (4), p.231-234
Main Authors: Panikabutra, K, Ariyarit, C, Chitwarakorn, A, Saensanoh, C
Format: Article
Language:English
Subjects:
4-Quinolones
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Gonorrhea - drug therapy
Humans
Male
Medical sciences
Microbial Sensitivity Tests
Neisseria gonorrhoeae
Neisseria gonorrhoeae - enzymology
Penicillinase - biosynthesis
Pharmacology. Drug treatments
Quinolines - therapeutic use
Quinolones
Spectinomycin - therapeutic use
Urethritis - drug therapy
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Summary:Between 3 January and 4 March 1983 we treated 200 male patients diagnosed as having uncomplicated gonococcal urethritis with one of two regimens. They were divided into two groups and randomly assigned to treatment with either 2 g spectinomycin administered intramuscularly (group A) or 300 mg rosoxacin by mouth (group B). Of 187 isolates tested for the production of beta-lactamase, 101 (54%) were penicillinase producing Neisseria gonorrhoeae (PPNG) strains. All 81 cases followed in group A (spectinomycin) were cured, compared with 88.5% (77 out of 87) of the patients followed in group B (rosoxacin). We concluded that rosoxacin at a dosage of 300 mg administered orally was fairly effective in the treatment of gonococcal urethritis in men caused by both PPNG and non-PPNG strains.
ISSN:0007-134X
1368-4973
1472-3263
DOI:10.1136/sti.60.4.231