Elevated Crude Mortality in Obese Chronic Kidney Disease Patients with Loss of Exercise Habit: A Cohort Study of the Japanese General Population

Objective The relationship between obesity and risk of death in chronic kidney disease (CKD) patients remains controversial. In addition, no clear evidence has been accumulated regarding whether or not exercise improves mortality in CKD patients. Methods The original cohort was based on a Japanese g...

Full description

Saved in:
Bibliographic Details
Published in:Internal Medicine 2023/08/01, Vol.62(15), pp.2171-2179
Main Authors: Harada, Takuya, Nagai, Kei, Mase, Kaori, Tsunoda, Ryoya, Iseki, Kunitoshi, Moriyama, Toshiki, Tsuruya, Kazuhiko, Fujimoto, Shouichi, Narita, Ichiei, Konta, Tsuneo, Kondo, Masahide, Kasahara, Masato, Shibagaki, Yugo, Asahi, Koichi, Watanabe, Tsuyoshi, Yamagata, Kunihiro
Format: Article
Language:English
Subjects:
Body mass index
Body weight gain
chronic kidney disease
Cohort analysis
exercise
Internal medicine
Kidney diseases
Mortality
Obesity
Original
Population studies
Sex ratio
Walking
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective The relationship between obesity and risk of death in chronic kidney disease (CKD) patients remains controversial. In addition, no clear evidence has been accumulated regarding whether or not exercise improves mortality in CKD patients. Methods The original cohort was based on a Japanese general population of 685,889 people from 40 to 74 years old who had undergone annual specific health checkups. The number of all-cause deaths during follow-up (mean, 4.7 years) in this study was 1,490. Information on walking and exercise habits was obtained by questionnaires. The study population was divided into 4 categories by the combination of CKD and obesity [body mass index (BMI) ≥25.0 kg/m2]. Changes in the BMI and walking and exercise habits were determined by results for the first year and following year. Results Obese CKD patients with weight gain (BMI increase by more than +1.0 kg/m2/year) showed a higher crude mortality (1.32%) than those with a stable BMI (within ±1.0 kg/m2/year; 0.69%). In the obese CKD population, mortality was higher with loss of exercise habits (0.96%) than in those continuously maintaining exercise habits (0.52%). The age- and sex-adjusted hazard ratio for all-cause death was 2.23 in the group with weight gain compared to the group with stable weight (p
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.0803-22