Case Series on DRESS: An Unpredictable Adverse Drug Reaction

Drug rash with eosinophilia and systemic symptoms syndrome (DRESS) is a potentially life-threatening, drug-induced, multi-organ system reaction. The most frequently involved organ is the liver, followed by the kidneys and lungs. Early detection and diagnosis followed by withdrawal of the offending a...

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Bibliographic Details
Published in:Mediterranean journal of rheumatology 2023-06, Vol.34 (2), p.245-251
Main Authors: Fatima, Maryam, Azimi, Salwa Sahar, Ashwini, Soumya, Radhakrishna, Madhuri H
Format: Article
Language:English
Subjects:
Abdomen
Antibiotics
Anticonvulsants
Biopsy
Case reports
Case Series
Edema
Erythema
Fever
Hospitals
Laboratories
Mortality
Pain
Side effects
Skin
Steroids
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Summary:Drug rash with eosinophilia and systemic symptoms syndrome (DRESS) is a potentially life-threatening, drug-induced, multi-organ system reaction. The most frequently involved organ is the liver, followed by the kidneys and lungs. Early detection and diagnosis followed by withdrawal of the offending agent is vital to minimise the associated morbidity and mortality, and a detailed drug history is vital to identify the causative drugs. Although Spanish guidelines were developed by a panel of allergy specialists from the Drug Allergy Committee of the Spanish Society of Allergy and Clinical Immunology (SEAIC) and are available in literature from 2020, many clinicians are still unaware about the management of this syndrome. Framing National guidelines for the early diagnosis and pharmaco-therapeutic management of DRESS will help healthcare professionals to save the patients from unintended vulnerability. We hereby present a case series on DRESS. Cite this article as: Fatima M, Azimi SS, Ashwini S, Radhakrishna MH. Case Series on DRESS: An Unpredictable Adverse Drug Reaction. Mediterr J Rheumatol 2023;34(2):245-51.
ISSN:2529-198X
2529-198X
DOI:10.31138/mjr.34.2.245