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A short-term intervention of ingesting iron along with methionine and threonine leads to a higher hemoglobin level than that with iron alone in young healthy women: a randomized, double-blind, parallel-group, comparative study
Purpose Enhancing iron absorption and utilization is important for amelioration iron status faster and thereby, for improving quality of life. Dietary protein and amino acids, including methionine and threonine, have been reported to facilitate the absorption and utilization of dietary iron. Here, w...
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| Published in: | European journal of nutrition 2023-10, Vol.62 (7), p.3009-3019 |
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| Main Authors: | , , , , , , , |
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| container_end_page | 3019 |
| container_issue | 7 |
| container_start_page | 3009 |
| container_title | European journal of nutrition |
| container_volume | 62 |
| creator | Tateishi, Yuko Toyoda, Sakiko Murakami, Hitoshi Uchida, Ryo Ichikawa, Reiko Kikuchi, Takuya Sato, Wataru Suzuki, Katsuya |
| description | Purpose
Enhancing iron absorption and utilization is important for amelioration iron status faster and thereby, for improving quality of life. Dietary protein and amino acids, including methionine and threonine, have been reported to facilitate the absorption and utilization of dietary iron. Here, we investigated the effect of combined ingestion of methionine, threonine, and iron on the improvement of iron status during a short-term intervention, by comparing that with iron ingestion alone in healthy young women.
Methods
This was a randomized, double-blind, parallel-group, comparative study with 45 participants (aged 20–39) randomly assigned to three groups (
n
= 15 each): one group was administered 200 mg methionine, 400 mg threonine, and 6 mg iron once daily (FEMT); another ingested 6 mg iron alone (FE); and the third group ingested a placebo (PCG). Blood samples and dietary nutrient data were collected before the intervention (week 0) and after 2, 4, and 6 weeks. Serum iron, hemoglobin, transferrin, and ferritin levels were measured.
Results
Blood hemoglobin levels were significantly higher in the FEMT than in the FE group (
P
|
| doi_str_mv | 10.1007/s00394-023-03213-w |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10468430</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2841023922</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-ca633f790ed068ec64a157b442fb255978f124729378597a8a51d091b6d931173</originalsourceid><addsrcrecordid>eNp9ksmO1DAQhiMEYoaGF-CALHHhMAFv2big0QhmkEbiAmfLSSqJR47d2E63msflSagmQ7McuNgu11d_efmz7Dmjrxml1ZtIqWhkTrnIqeBM5PsH2TmTosxLzoqHpzWtzrInMd5RimjJHmdnopI1FWV1nn2_JHHyIeUJwkyMw2kHLhnviB8wHiEmHIkJuKOtx-XepInMkCaEjAOiXU_SFGCNLOg-kuSJJpMZJwhkgtmP1rfGYXIHFmHtjkNapU7SgP3IwS_YYwJt03Qgez-De4taAbv42XyD_oL0fmkt5K01DqOtDtpasPkY_LK9IJ2fj1vJ7IDEtPSHp9mjQdsIz-7nTfblw_vPVzf57afrj1eXt3kneZnyTpdCDFVDoadlDV0pNSuqVko-tLwomqoeGJcVb0RVY6RrXbCeNqwt-0YwVolN9m7V3S7tDH2Hz4gnU9tgZh0Oymuj_s44M6nR7xSjsqyloKjw6l4h-K8LvryaTezAWu3AL1HxWjL8woZzRF_-g975JTi8H1JFXVPeoCM2GV-pLvgYAwyn0zCqjh5Sq4cUqqqfHlJ7LHrx5z1OJb9Mg4BYgYgpdEj43fs_sj8AiLrXwA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2858802921</pqid></control><display><type>article</type><title>A short-term intervention of ingesting iron along with methionine and threonine leads to a higher hemoglobin level than that with iron alone in young healthy women: a randomized, double-blind, parallel-group, comparative study</title><source>SPORTDiscus database</source><source>Springer Link</source><creator>Tateishi, Yuko ; Toyoda, Sakiko ; Murakami, Hitoshi ; Uchida, Ryo ; Ichikawa, Reiko ; Kikuchi, Takuya ; Sato, Wataru ; Suzuki, Katsuya</creator><creatorcontrib>Tateishi, Yuko ; Toyoda, Sakiko ; Murakami, Hitoshi ; Uchida, Ryo ; Ichikawa, Reiko ; Kikuchi, Takuya ; Sato, Wataru ; Suzuki, Katsuya</creatorcontrib><description>Purpose
Enhancing iron absorption and utilization is important for amelioration iron status faster and thereby, for improving quality of life. Dietary protein and amino acids, including methionine and threonine, have been reported to facilitate the absorption and utilization of dietary iron. Here, we investigated the effect of combined ingestion of methionine, threonine, and iron on the improvement of iron status during a short-term intervention, by comparing that with iron ingestion alone in healthy young women.
Methods
This was a randomized, double-blind, parallel-group, comparative study with 45 participants (aged 20–39) randomly assigned to three groups (
n
= 15 each): one group was administered 200 mg methionine, 400 mg threonine, and 6 mg iron once daily (FEMT); another ingested 6 mg iron alone (FE); and the third group ingested a placebo (PCG). Blood samples and dietary nutrient data were collected before the intervention (week 0) and after 2, 4, and 6 weeks. Serum iron, hemoglobin, transferrin, and ferritin levels were measured.
Results
Blood hemoglobin levels were significantly higher in the FEMT than in the FE group (
P
< 0.05) at week 4. Serum iron, transferrin, and ferritin levels were not changed across groups. In addition, our analyses showed that the observed increase in hemoglobin levels was affected by the intervention rather than changes in dietary nutrient intake.
Conclusions
Ingestion of methionine and threonine with low doses of iron leads to a higher hemoglobin levels than that with iron alone in a short period of 4 weeks.
Trial registration
University Hospital Medical Information Network Clinical Trial Registry (UMIN000046621).</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-023-03213-w</identifier><identifier>PMID: 37480367</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Chemistry ; Chemistry and Materials Science ; Clinical trials ; Dietary intake ; Double-blind studies ; Ferritin ; Hemoglobin ; Iron ; Methionine ; Nutrition ; Original Contribution ; Quality of life ; Threonine ; Transferrins ; UMIN ; UMIN000046621</subject><ispartof>European journal of nutrition, 2023-10, Vol.62 (7), p.3009-3019</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-ca633f790ed068ec64a157b442fb255978f124729378597a8a51d091b6d931173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37480367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tateishi, Yuko</creatorcontrib><creatorcontrib>Toyoda, Sakiko</creatorcontrib><creatorcontrib>Murakami, Hitoshi</creatorcontrib><creatorcontrib>Uchida, Ryo</creatorcontrib><creatorcontrib>Ichikawa, Reiko</creatorcontrib><creatorcontrib>Kikuchi, Takuya</creatorcontrib><creatorcontrib>Sato, Wataru</creatorcontrib><creatorcontrib>Suzuki, Katsuya</creatorcontrib><title>A short-term intervention of ingesting iron along with methionine and threonine leads to a higher hemoglobin level than that with iron alone in young healthy women: a randomized, double-blind, parallel-group, comparative study</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
Enhancing iron absorption and utilization is important for amelioration iron status faster and thereby, for improving quality of life. Dietary protein and amino acids, including methionine and threonine, have been reported to facilitate the absorption and utilization of dietary iron. Here, we investigated the effect of combined ingestion of methionine, threonine, and iron on the improvement of iron status during a short-term intervention, by comparing that with iron ingestion alone in healthy young women.
Methods
This was a randomized, double-blind, parallel-group, comparative study with 45 participants (aged 20–39) randomly assigned to three groups (
n
= 15 each): one group was administered 200 mg methionine, 400 mg threonine, and 6 mg iron once daily (FEMT); another ingested 6 mg iron alone (FE); and the third group ingested a placebo (PCG). Blood samples and dietary nutrient data were collected before the intervention (week 0) and after 2, 4, and 6 weeks. Serum iron, hemoglobin, transferrin, and ferritin levels were measured.
Results
Blood hemoglobin levels were significantly higher in the FEMT than in the FE group (
P
< 0.05) at week 4. Serum iron, transferrin, and ferritin levels were not changed across groups. In addition, our analyses showed that the observed increase in hemoglobin levels was affected by the intervention rather than changes in dietary nutrient intake.
Conclusions
Ingestion of methionine and threonine with low doses of iron leads to a higher hemoglobin levels than that with iron alone in a short period of 4 weeks.
Trial registration
University Hospital Medical Information Network Clinical Trial Registry (UMIN000046621).</description><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Clinical trials</subject><subject>Dietary intake</subject><subject>Double-blind studies</subject><subject>Ferritin</subject><subject>Hemoglobin</subject><subject>Iron</subject><subject>Methionine</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Quality of life</subject><subject>Threonine</subject><subject>Transferrins</subject><subject>UMIN</subject><subject>UMIN000046621</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9ksmO1DAQhiMEYoaGF-CALHHhMAFv2big0QhmkEbiAmfLSSqJR47d2E63msflSagmQ7McuNgu11d_efmz7Dmjrxml1ZtIqWhkTrnIqeBM5PsH2TmTosxLzoqHpzWtzrInMd5RimjJHmdnopI1FWV1nn2_JHHyIeUJwkyMw2kHLhnviB8wHiEmHIkJuKOtx-XepInMkCaEjAOiXU_SFGCNLOg-kuSJJpMZJwhkgtmP1rfGYXIHFmHtjkNapU7SgP3IwS_YYwJt03Qgez-De4taAbv42XyD_oL0fmkt5K01DqOtDtpasPkY_LK9IJ2fj1vJ7IDEtPSHp9mjQdsIz-7nTfblw_vPVzf57afrj1eXt3kneZnyTpdCDFVDoadlDV0pNSuqVko-tLwomqoeGJcVb0RVY6RrXbCeNqwt-0YwVolN9m7V3S7tDH2Hz4gnU9tgZh0Oymuj_s44M6nR7xSjsqyloKjw6l4h-K8LvryaTezAWu3AL1HxWjL8woZzRF_-g975JTi8H1JFXVPeoCM2GV-pLvgYAwyn0zCqjh5Sq4cUqqqfHlJ7LHrx5z1OJb9Mg4BYgYgpdEj43fs_sj8AiLrXwA</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Tateishi, Yuko</creator><creator>Toyoda, Sakiko</creator><creator>Murakami, Hitoshi</creator><creator>Uchida, Ryo</creator><creator>Ichikawa, Reiko</creator><creator>Kikuchi, Takuya</creator><creator>Sato, Wataru</creator><creator>Suzuki, Katsuya</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20231001</creationdate><title>A short-term intervention of ingesting iron along with methionine and threonine leads to a higher hemoglobin level than that with iron alone in young healthy women: a randomized, double-blind, parallel-group, comparative study</title><author>Tateishi, Yuko ; Toyoda, Sakiko ; Murakami, Hitoshi ; Uchida, Ryo ; Ichikawa, Reiko ; Kikuchi, Takuya ; Sato, Wataru ; Suzuki, Katsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-ca633f790ed068ec64a157b442fb255978f124729378597a8a51d091b6d931173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Clinical trials</topic><topic>Dietary intake</topic><topic>Double-blind studies</topic><topic>Ferritin</topic><topic>Hemoglobin</topic><topic>Iron</topic><topic>Methionine</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>Quality of life</topic><topic>Threonine</topic><topic>Transferrins</topic><topic>UMIN</topic><topic>UMIN000046621</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tateishi, Yuko</creatorcontrib><creatorcontrib>Toyoda, Sakiko</creatorcontrib><creatorcontrib>Murakami, Hitoshi</creatorcontrib><creatorcontrib>Uchida, Ryo</creatorcontrib><creatorcontrib>Ichikawa, Reiko</creatorcontrib><creatorcontrib>Kikuchi, Takuya</creatorcontrib><creatorcontrib>Sato, Wataru</creatorcontrib><creatorcontrib>Suzuki, Katsuya</creatorcontrib><collection>SpringerOpen website</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tateishi, Yuko</au><au>Toyoda, Sakiko</au><au>Murakami, Hitoshi</au><au>Uchida, Ryo</au><au>Ichikawa, Reiko</au><au>Kikuchi, Takuya</au><au>Sato, Wataru</au><au>Suzuki, Katsuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A short-term intervention of ingesting iron along with methionine and threonine leads to a higher hemoglobin level than that with iron alone in young healthy women: a randomized, double-blind, parallel-group, comparative study</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>62</volume><issue>7</issue><spage>3009</spage><epage>3019</epage><pages>3009-3019</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
Enhancing iron absorption and utilization is important for amelioration iron status faster and thereby, for improving quality of life. Dietary protein and amino acids, including methionine and threonine, have been reported to facilitate the absorption and utilization of dietary iron. Here, we investigated the effect of combined ingestion of methionine, threonine, and iron on the improvement of iron status during a short-term intervention, by comparing that with iron ingestion alone in healthy young women.
Methods
This was a randomized, double-blind, parallel-group, comparative study with 45 participants (aged 20–39) randomly assigned to three groups (
n
= 15 each): one group was administered 200 mg methionine, 400 mg threonine, and 6 mg iron once daily (FEMT); another ingested 6 mg iron alone (FE); and the third group ingested a placebo (PCG). Blood samples and dietary nutrient data were collected before the intervention (week 0) and after 2, 4, and 6 weeks. Serum iron, hemoglobin, transferrin, and ferritin levels were measured.
Results
Blood hemoglobin levels were significantly higher in the FEMT than in the FE group (
P
< 0.05) at week 4. Serum iron, transferrin, and ferritin levels were not changed across groups. In addition, our analyses showed that the observed increase in hemoglobin levels was affected by the intervention rather than changes in dietary nutrient intake.
Conclusions
Ingestion of methionine and threonine with low doses of iron leads to a higher hemoglobin levels than that with iron alone in a short period of 4 weeks.
Trial registration
University Hospital Medical Information Network Clinical Trial Registry (UMIN000046621).</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37480367</pmid><doi>10.1007/s00394-023-03213-w</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of nutrition, 2023-10, Vol.62 (7), p.3009-3019 |
| issn | 1436-6207 1436-6215 |
| language | eng |
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| source | SPORTDiscus database; Springer Link |
| subjects | Chemistry Chemistry and Materials Science Clinical trials Dietary intake Double-blind studies Ferritin Hemoglobin Iron Methionine Nutrition Original Contribution Quality of life Threonine Transferrins UMIN UMIN000046621 |
| title | A short-term intervention of ingesting iron along with methionine and threonine leads to a higher hemoglobin level than that with iron alone in young healthy women: a randomized, double-blind, parallel-group, comparative study |
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