Dynamic players and intricate interactions: An integrated investigation of the Mla lipid transport system

The Maintenance of outer membrane (OM) Lipid Asymmetry system mediates retrograde phospholipid transport from the OM to the inner membrane (IM) in Gram-negative bacteria. However, the interactions between the various subunits of the IM and OM complexes are not well understood. In a recent study in 2...

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Bibliographic Details
Published in:The Journal of biological chemistry 2023-09, Vol.299 (9), p.105146, Article 105146
Main Authors: Ng, Dixon, Moraes, Trevor F.
Format: Article
Language:English
Subjects:
Bacterial Outer Membrane - chemistry
Bacterial Outer Membrane - metabolism
Bacterial Outer Membrane Proteins - chemistry
Bacterial Outer Membrane Proteins - metabolism
Biological Transport
Editors' Pick Highlight
Gram-Negative Bacteria - cytology
Gram-Negative Bacteria - metabolism
Lipid Metabolism
Membrane Lipids - metabolism
Phospholipids - metabolism
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Summary:The Maintenance of outer membrane (OM) Lipid Asymmetry system mediates retrograde phospholipid transport from the OM to the inner membrane (IM) in Gram-negative bacteria. However, the interactions between the various subunits of the IM and OM complexes are not well understood. In a recent study in 2023 by MacRae et al. in the Journal of Biological Chemistry, the authors examine components in the Maintenance of OM Lipid Asymmetry complex, define the interaction interfaces between members of the pathway, and propose a molecular model of the lipid transfer process from the OM to the IM that will help elucidate intricacies of lipid transport.
ISSN:0021-9258
1083-351X
1083-351X
DOI:10.1016/j.jbc.2023.105146