Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis

We compared esophageal mucosal gene transcript expression in proton pump inhibitor (PPI) responsive (PPI-R) eosinophilic esophagitis (EoE), PPI nonresponsive (PPI-NR) EoE, and healthy controls. Transcript expression in midesophagus biopsies was determined using NanoString and a custom panel of EoE-s...

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Bibliographic Details
Published in:Clinical and translational gastroenterology 2022-11, Vol.13 (11), p.e00540-e00540
Main Authors: Hamilton, Matthew J., Muftah, Mayssan, Goldin, Alison H., Lo, Wai-Kit, Hsu Blatman, Karen S., Chan, Walter W., Srivastava, Amitabh
Format: Article
Language:English
Subjects:
Biopsy
Brief Report
Eosinophilic Esophagitis - diagnosis
Eosinophilic Esophagitis - drug therapy
Eosinophilic Esophagitis - genetics
Esophagus
Humans
Proton Pump Inhibitors - pharmacology
Proton Pump Inhibitors - therapeutic use
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Summary:We compared esophageal mucosal gene transcript expression in proton pump inhibitor (PPI) responsive (PPI-R) eosinophilic esophagitis (EoE), PPI nonresponsive (PPI-NR) EoE, and healthy controls. Transcript expression in midesophagus biopsies was determined using NanoString and a custom panel of EoE-specific genes. The top upregulated and downregulated genes with ≥2-fold difference in expression and statistically significant ( P < 0.05) were identified. Nearly all the top upregulated (17 of 20) and downregulated (5 of 5) genes in EoE, compared with healthy controls, were shared between the PPI-R and PPI-NR groups. Esophageal mucosal transcript expressions are remarkably similar in PPI-R EoE and PPI-NR EoE compared with healthy controls.
ISSN:2155-384X
2155-384X
DOI:10.14309/ctg.0000000000000540