Breakthrough COVID-19 infections – Analyzing our experience

Objective: There are many cases of post-vaccination COVID-19 globally. Also, literature on serum antibodies after vaccination is abundant. Our research focuses on breakthrough infections reported at our institution during the third wave of COVID-19. Methods: A total of 177 people recruited at the In...

Full description

Saved in:
Bibliographic Details
Published in:Pakistan journal of medical sciences 2023-10, Vol.39 (5), p.1225-1231
Main Authors: Hussain, Aneela, Sarfaraz, Samreen, Anis, Sabiha, Shaikh, Quratulain, Rahim, Anum, Behram, Shameem, Shah, Rabeea, Khan, Owais
Format: Article
Language:English
Subjects:
Antibodies
Asymptomatic
Comorbidity
COVID-19
COVID-19 vaccines
Disease transmission
Gender
Health aspects
Hospitalization
Hospitals
Hypertension
Immunoglobulin G
Infection
Infections
Medical personnel
Original
Severe acute respiratory syndrome coronavirus 2
Vaccination
Vaccines
World health
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: There are many cases of post-vaccination COVID-19 globally. Also, literature on serum antibodies after vaccination is abundant. Our research focuses on breakthrough infections reported at our institution during the third wave of COVID-19. Methods: A total of 177 people recruited at the Indus Hospital Karachi between May to September 2021 with COVID-19 infection were divided into vaccinated, partially vaccinated, and unvaccinated cohorts. Furthermore, a subset of the vaccinated cohort was tested for anti-NP and anti-S antibodies. Results: There were 119 patients with breakthrough infection, however, 74% had mild symptoms. The antibodies against NP and S were found at a higher level in those who had a breakthrough infection in comparison to healthy vaccinated controls. Conclusion: Vaccination does not prevent disease but does confer some immunity causing less severe infection. doi: https://doi.org/10.12669/pjms.39.5.6724 How to cite this: Hussain A, Sarfaraz S, Anis S, Sheikh Q, Rahim A, Behram S, et al. Breakthrough COVID-19 infections – Analyzing our experience. Pak J Med Sci. 2023;39(5):---. doi: https://doi.org/10.12669/pjms.39.5.6724 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ISSN:1682-024X
1681-715X
DOI:10.12669/PJMS.39.5.6724