Yield & accuracy of Gastric Lavage in non-expectorating adults with Suspected Pulmonary Tuberculosis

Objective: To determine the yield of Gastric lavage (GL) in non-expectorating adults with suspected Pulmonary Tuberculosis (PTB) and accuracy of GL-AFB smear with GL-GeneXpert (GXP) by taking AFB culture as gold standard. Methods: Cross-sectional study on suspected PTB patients was done at Ojha Inst...

Full description

Saved in:
Bibliographic Details
Published in:Pakistan journal of medical sciences 2023-10, Vol.39 (5), p.1468-1472
Main Authors: Ghafoor, Lubna, Zuberi, Faisal Faiyaz, Khan, Ghulam Muqtada, Ismail, Maria
Format: Article
Language:English
Subjects:
Accuracy
Adults
Cavitation
Complaints
Developing countries
Drug resistance
Esophagus
Females
Fever
Gastric lavage
Gender
LDCs
Original
Patients
Pulmonary tuberculosis
Tuberculosis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 1472
container_issue 5
container_start_page 1468
container_title Pakistan journal of medical sciences
container_volume 39
creator Ghafoor, Lubna
Zuberi, Faisal Faiyaz
Khan, Ghulam Muqtada
Ismail, Maria
description Objective: To determine the yield of Gastric lavage (GL) in non-expectorating adults with suspected Pulmonary Tuberculosis (PTB) and accuracy of GL-AFB smear with GL-GeneXpert (GXP) by taking AFB culture as gold standard. Methods: Cross-sectional study on suspected PTB patients was done at Ojha Institute of Chest Diseases during period 16th July 2020 till 15th January 2021. Adult patients of either gender suspected to have PTB and not expectorating were included. GL was performed and sent for AFB smear, GXP and AFB culture. Odds ratio, sensitivity and specificity were calculated. Results: After informed written consent, 206 patients, mean age was 38.17 ±17.30 years were inducted, including 89 (43.2%) males and 117 (56.8%) females. Gene Xpert, AFB smear & AFB culture were positive in 83(40%), 50 (24%) & 72 (35%) respectively in GL samples. Odds of PTB were 3.95 times higher among patients with ≤1 month of duration of symptoms (aOR 3.95, 95% CI 1.82-8.57, p-value 0.001), 6.24 times higher among patients with weight loss (aOR 6.24, 95% CI 3.03-12.84, p-value
doi_str_mv 10.12669/pjms.39.5.6972
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10480766</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A760264687</galeid><sourcerecordid>A760264687</sourcerecordid><originalsourceid>FETCH-LOGICAL-c340t-1a7de193f3b981b7b2d0207be2c466a23fe08eaadd38f05cb29db6f4660dab1b3</originalsourceid><addsrcrecordid>eNptks1rFTEUxQdRsNSu3QaE4mam-ZhJZlZSiq3CAwUr1FXIx533UjLJM5lU-9870xb1iWSRkPO7J_eGU1WvCW4I5Xw4299OuWFD0zV8EPRZdUR4T2pBupvnD2daY9revKxOcnYaY9wxLAQ5quw3B96iU6SMKUmZexRHdKXynJxBG3WntoBcQCGGGn7uwcwxqdmFLVK2-DmjH27eoS8lrxJY9Ln4KQaV7tF10ZBM8TG7_Kp6MSqf4eRpP66-Xr6_vvhQbz5dfbw439SGtXiuiRIWyMBGpoeeaKGpxRQLDdS0nCvKRsA9KGUt60fcGU0Hq_m4aNgqTTQ7rt49-u6LnsAaCHNSXu6Tm5aWZFROHirB7eQ23kmC2x4LzheHt08OKX4vkGc5uWzAexUglixpzxkdOjys6Jt_0NtYUljmW6i2bxkVfPhDbZUH6cIYl4fNairPBceUt7wXC9X8h1qWhcmZGGB0y_1BwelfBTtQft7l6MvsYsiH4NkjaFLMOcH4-zcIlg_RkWt0JBtkJ9fosF-2vrg8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2848432769</pqid></control><display><type>article</type><title>Yield &amp; accuracy of Gastric Lavage in non-expectorating adults with Suspected Pulmonary Tuberculosis</title><source>Nexis UK</source><source>PubMed Central</source><creator>Ghafoor, Lubna ; Zuberi, Faisal Faiyaz ; Khan, Ghulam Muqtada ; Ismail, Maria</creator><creatorcontrib>Ghafoor, Lubna ; Zuberi, Faisal Faiyaz ; Khan, Ghulam Muqtada ; Ismail, Maria</creatorcontrib><description>Objective: To determine the yield of Gastric lavage (GL) in non-expectorating adults with suspected Pulmonary Tuberculosis (PTB) and accuracy of GL-AFB smear with GL-GeneXpert (GXP) by taking AFB culture as gold standard. Methods: Cross-sectional study on suspected PTB patients was done at Ojha Institute of Chest Diseases during period 16th July 2020 till 15th January 2021. Adult patients of either gender suspected to have PTB and not expectorating were included. GL was performed and sent for AFB smear, GXP and AFB culture. Odds ratio, sensitivity and specificity were calculated. Results: After informed written consent, 206 patients, mean age was 38.17 ±17.30 years were inducted, including 89 (43.2%) males and 117 (56.8%) females. Gene Xpert, AFB smear &amp; AFB culture were positive in 83(40%), 50 (24%) &amp; 72 (35%) respectively in GL samples. Odds of PTB were 3.95 times higher among patients with ≤1 month of duration of symptoms (aOR 3.95, 95% CI 1.82-8.57, p-value 0.001), 6.24 times higher among patients with weight loss (aOR 6.24, 95% CI 3.03-12.84, p-value &lt;0.001), and 4.22 times higher among patients with cavitation (aOR 4.22, 95% CI 1.99-8.93, p-value &lt;0.001). GL-AFB smear showed sensitivity 63.89%, specificity 97.01%, positive predicted value 92%, negative predicted value 83.3%, and overall diagnostic accuracy 85.4%. Whereas GL-GXP showed sensitivity 94.4%, specificity 88.81%, positive predicted value 81.93%, negative predicted value 96.75%, and overall diagnostic accuracy 90.78%. Conclusion: Yield of GL significant to detect PTB in suspected cases who are not expectorating. GL-GXP diagnostic accuracy and sensitivity is higher than GL-AFB smear. doi: https://doi.org/10.12669/pjms.39.5.6972 How to cite this: Ghafoor L, Zuberi FF, Khan GM, Ismail M. Yield &amp; accuracy of Gastric Lavage in non-expectorating adults with Suspected Pulmonary Tuberculosis. Pak J Med Sci. 2023;39(5):---. doi: https://doi.org/10.12669/pjms.39.5.6972 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</description><identifier>ISSN: 1682-024X</identifier><identifier>EISSN: 1681-715X</identifier><identifier>DOI: 10.12669/pjms.39.5.6972</identifier><language>eng</language><publisher>Karachi: Knowledge Bylanes</publisher><subject>Accuracy ; Adults ; Cavitation ; Complaints ; Developing countries ; Drug resistance ; Esophagus ; Females ; Fever ; Gastric lavage ; Gender ; LDCs ; Original ; Patients ; Pulmonary tuberculosis ; Tuberculosis</subject><ispartof>Pakistan journal of medical sciences, 2023-10, Vol.39 (5), p.1468-1472</ispartof><rights>COPYRIGHT 2023 Knowledge Bylanes</rights><rights>(c)2023 Pakistan Journal of Medical Sciences</rights><rights>Copyright: © Pakistan Journal of Medical Sciences 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-9067-0021</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480766/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480766/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27898,27899,53763,53765</link.rule.ids></links><search><creatorcontrib>Ghafoor, Lubna</creatorcontrib><creatorcontrib>Zuberi, Faisal Faiyaz</creatorcontrib><creatorcontrib>Khan, Ghulam Muqtada</creatorcontrib><creatorcontrib>Ismail, Maria</creatorcontrib><title>Yield &amp; accuracy of Gastric Lavage in non-expectorating adults with Suspected Pulmonary Tuberculosis</title><title>Pakistan journal of medical sciences</title><description>Objective: To determine the yield of Gastric lavage (GL) in non-expectorating adults with suspected Pulmonary Tuberculosis (PTB) and accuracy of GL-AFB smear with GL-GeneXpert (GXP) by taking AFB culture as gold standard. Methods: Cross-sectional study on suspected PTB patients was done at Ojha Institute of Chest Diseases during period 16th July 2020 till 15th January 2021. Adult patients of either gender suspected to have PTB and not expectorating were included. GL was performed and sent for AFB smear, GXP and AFB culture. Odds ratio, sensitivity and specificity were calculated. Results: After informed written consent, 206 patients, mean age was 38.17 ±17.30 years were inducted, including 89 (43.2%) males and 117 (56.8%) females. Gene Xpert, AFB smear &amp; AFB culture were positive in 83(40%), 50 (24%) &amp; 72 (35%) respectively in GL samples. Odds of PTB were 3.95 times higher among patients with ≤1 month of duration of symptoms (aOR 3.95, 95% CI 1.82-8.57, p-value 0.001), 6.24 times higher among patients with weight loss (aOR 6.24, 95% CI 3.03-12.84, p-value &lt;0.001), and 4.22 times higher among patients with cavitation (aOR 4.22, 95% CI 1.99-8.93, p-value &lt;0.001). GL-AFB smear showed sensitivity 63.89%, specificity 97.01%, positive predicted value 92%, negative predicted value 83.3%, and overall diagnostic accuracy 85.4%. Whereas GL-GXP showed sensitivity 94.4%, specificity 88.81%, positive predicted value 81.93%, negative predicted value 96.75%, and overall diagnostic accuracy 90.78%. Conclusion: Yield of GL significant to detect PTB in suspected cases who are not expectorating. GL-GXP diagnostic accuracy and sensitivity is higher than GL-AFB smear. doi: https://doi.org/10.12669/pjms.39.5.6972 How to cite this: Ghafoor L, Zuberi FF, Khan GM, Ismail M. Yield &amp; accuracy of Gastric Lavage in non-expectorating adults with Suspected Pulmonary Tuberculosis. Pak J Med Sci. 2023;39(5):---. doi: https://doi.org/10.12669/pjms.39.5.6972 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</description><subject>Accuracy</subject><subject>Adults</subject><subject>Cavitation</subject><subject>Complaints</subject><subject>Developing countries</subject><subject>Drug resistance</subject><subject>Esophagus</subject><subject>Females</subject><subject>Fever</subject><subject>Gastric lavage</subject><subject>Gender</subject><subject>LDCs</subject><subject>Original</subject><subject>Patients</subject><subject>Pulmonary tuberculosis</subject><subject>Tuberculosis</subject><issn>1682-024X</issn><issn>1681-715X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNptks1rFTEUxQdRsNSu3QaE4mam-ZhJZlZSiq3CAwUr1FXIx533UjLJM5lU-9870xb1iWSRkPO7J_eGU1WvCW4I5Xw4299OuWFD0zV8EPRZdUR4T2pBupvnD2daY9revKxOcnYaY9wxLAQ5quw3B96iU6SMKUmZexRHdKXynJxBG3WntoBcQCGGGn7uwcwxqdmFLVK2-DmjH27eoS8lrxJY9Ln4KQaV7tF10ZBM8TG7_Kp6MSqf4eRpP66-Xr6_vvhQbz5dfbw439SGtXiuiRIWyMBGpoeeaKGpxRQLDdS0nCvKRsA9KGUt60fcGU0Hq_m4aNgqTTQ7rt49-u6LnsAaCHNSXu6Tm5aWZFROHirB7eQ23kmC2x4LzheHt08OKX4vkGc5uWzAexUglixpzxkdOjys6Jt_0NtYUljmW6i2bxkVfPhDbZUH6cIYl4fNairPBceUt7wXC9X8h1qWhcmZGGB0y_1BwelfBTtQft7l6MvsYsiH4NkjaFLMOcH4-zcIlg_RkWt0JBtkJ9fosF-2vrg8</recordid><startdate>20231031</startdate><enddate>20231031</enddate><creator>Ghafoor, Lubna</creator><creator>Zuberi, Faisal Faiyaz</creator><creator>Khan, Ghulam Muqtada</creator><creator>Ismail, Maria</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><general>Professional Medical Publications</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9067-0021</orcidid></search><sort><creationdate>20231031</creationdate><title>Yield &amp; accuracy of Gastric Lavage in non-expectorating adults with Suspected Pulmonary Tuberculosis</title><author>Ghafoor, Lubna ; Zuberi, Faisal Faiyaz ; Khan, Ghulam Muqtada ; Ismail, Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-1a7de193f3b981b7b2d0207be2c466a23fe08eaadd38f05cb29db6f4660dab1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Accuracy</topic><topic>Adults</topic><topic>Cavitation</topic><topic>Complaints</topic><topic>Developing countries</topic><topic>Drug resistance</topic><topic>Esophagus</topic><topic>Females</topic><topic>Fever</topic><topic>Gastric lavage</topic><topic>Gender</topic><topic>LDCs</topic><topic>Original</topic><topic>Patients</topic><topic>Pulmonary tuberculosis</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghafoor, Lubna</creatorcontrib><creatorcontrib>Zuberi, Faisal Faiyaz</creatorcontrib><creatorcontrib>Khan, Ghulam Muqtada</creatorcontrib><creatorcontrib>Ismail, Maria</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health &amp; Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pakistan journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghafoor, Lubna</au><au>Zuberi, Faisal Faiyaz</au><au>Khan, Ghulam Muqtada</au><au>Ismail, Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Yield &amp; accuracy of Gastric Lavage in non-expectorating adults with Suspected Pulmonary Tuberculosis</atitle><jtitle>Pakistan journal of medical sciences</jtitle><date>2023-10-31</date><risdate>2023</risdate><volume>39</volume><issue>5</issue><spage>1468</spage><epage>1472</epage><pages>1468-1472</pages><issn>1682-024X</issn><eissn>1681-715X</eissn><abstract>Objective: To determine the yield of Gastric lavage (GL) in non-expectorating adults with suspected Pulmonary Tuberculosis (PTB) and accuracy of GL-AFB smear with GL-GeneXpert (GXP) by taking AFB culture as gold standard. Methods: Cross-sectional study on suspected PTB patients was done at Ojha Institute of Chest Diseases during period 16th July 2020 till 15th January 2021. Adult patients of either gender suspected to have PTB and not expectorating were included. GL was performed and sent for AFB smear, GXP and AFB culture. Odds ratio, sensitivity and specificity were calculated. Results: After informed written consent, 206 patients, mean age was 38.17 ±17.30 years were inducted, including 89 (43.2%) males and 117 (56.8%) females. Gene Xpert, AFB smear &amp; AFB culture were positive in 83(40%), 50 (24%) &amp; 72 (35%) respectively in GL samples. Odds of PTB were 3.95 times higher among patients with ≤1 month of duration of symptoms (aOR 3.95, 95% CI 1.82-8.57, p-value 0.001), 6.24 times higher among patients with weight loss (aOR 6.24, 95% CI 3.03-12.84, p-value &lt;0.001), and 4.22 times higher among patients with cavitation (aOR 4.22, 95% CI 1.99-8.93, p-value &lt;0.001). GL-AFB smear showed sensitivity 63.89%, specificity 97.01%, positive predicted value 92%, negative predicted value 83.3%, and overall diagnostic accuracy 85.4%. Whereas GL-GXP showed sensitivity 94.4%, specificity 88.81%, positive predicted value 81.93%, negative predicted value 96.75%, and overall diagnostic accuracy 90.78%. Conclusion: Yield of GL significant to detect PTB in suspected cases who are not expectorating. GL-GXP diagnostic accuracy and sensitivity is higher than GL-AFB smear. doi: https://doi.org/10.12669/pjms.39.5.6972 How to cite this: Ghafoor L, Zuberi FF, Khan GM, Ismail M. Yield &amp; accuracy of Gastric Lavage in non-expectorating adults with Suspected Pulmonary Tuberculosis. Pak J Med Sci. 2023;39(5):---. doi: https://doi.org/10.12669/pjms.39.5.6972 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</abstract><cop>Karachi</cop><pub>Knowledge Bylanes</pub><doi>10.12669/pjms.39.5.6972</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-9067-0021</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1682-024X
ispartof Pakistan journal of medical sciences, 2023-10, Vol.39 (5), p.1468-1472
issn 1682-024X
1681-715X
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10480766
source Nexis UK; PubMed Central
subjects Accuracy
Adults
Cavitation
Complaints
Developing countries
Drug resistance
Esophagus
Females
Fever
Gastric lavage
Gender
LDCs
Original
Patients
Pulmonary tuberculosis
Tuberculosis
title Yield & accuracy of Gastric Lavage in non-expectorating adults with Suspected Pulmonary Tuberculosis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-26T16%3A00%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Yield%20&%20accuracy%20of%20Gastric%20Lavage%20in%20non-expectorating%20adults%20with%20Suspected%20Pulmonary%20Tuberculosis&rft.jtitle=Pakistan%20journal%20of%20medical%20sciences&rft.au=Ghafoor,%20Lubna&rft.date=2023-10-31&rft.volume=39&rft.issue=5&rft.spage=1468&rft.epage=1472&rft.pages=1468-1472&rft.issn=1682-024X&rft.eissn=1681-715X&rft_id=info:doi/10.12669/pjms.39.5.6972&rft_dat=%3Cgale_pubme%3EA760264687%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c340t-1a7de193f3b981b7b2d0207be2c466a23fe08eaadd38f05cb29db6f4660dab1b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2848432769&rft_id=info:pmid/&rft_galeid=A760264687&rfr_iscdi=true