Can High-Frequency Intraoral Ultrasound Predict Histological Risk Factors in Oral Squamous Cell Carcinoma? A Preliminary Experience

• Published in: Cancers 2023-09, Vol.15 (17), p.4413
• Main Authors: Caprioli, Simone, Giordano, Giorgio-Gregory, Pennacchi, Alessia, Campagnari, Valentina, Iandelli, Andrea, Parrinello, Giampiero, Conforti, Cristina, Gili, Riccardo, Giannini, Edoardo, Marabotto, Elisa, Kayali, Stefano, Bianchi, Bernardo, Peretti, Giorgio, Cittadini, Giuseppe, Marchi, Filippo
• Format: Article
• Language: English
• Subjects: Biopsy; Cancer; Magnetic resonance imaging; Medical prognosis; Medical research; Medicine, Experimental; Metastasis; Morphology; Oral carcinoma; Oral cavity; Oral squamous cell carcinoma; Patients; Prognosis; Risk assessment; Risk factors; Squamous cell carcinoma; Surgeons; Tongue; Ultrasonic imaging; Ultrasound imaging
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers15174413

Despite advancements in multidisciplinary care, oncologic outcomes of oral cavity squamous cell carcinoma (OSCC) have not substantially improved: still, one-third of patients affected by stage I and II can develop locoregional recurrences. Imaging plays a pivotal role in preoperative staging of OSCC, providing depth of invasion (DOI) measurements. However, locoregional recurrences have a strong association with adverse histopathological factors not included in the staging system, and any imaging features linked to them have been lacking. In this study, the possibility to predict histological risk factors in OSCC with high-frequency intraoral ultrasonography (IOUS) was evaluated. Thirty-four patients were enrolled. The agreement between ultrasonographic and pathological DOI was evaluated, and ultrasonographic margins’ appearance was compared to the Brandwein-Gensler score and the worst pattern of invasion (WPOI). Excellent agreement between ultrasonographic and pathological DOI was found (mean difference: 0.2 mm). A significant relationship was found between ultrasonographic morphology of the front of infiltration and both Brandwein-Gensler score ≥ 3 (p < 0.0001) and WPOI ≥4 (p = 0.0001). Sensitivity, specificity, positive predictive value, and negative predictive value for the IOUS to predict a Brandwein-Gensler score ≥3 were 93.33%, 89.47%, 87.50%, and 94.44%, respectively. The present study demonstrated the promising role of IOUS in aiding risk stratification for OSCC patients.