NK and T Cell Subtypes in the Endometrium of Patients with Recurrent Pregnancy Loss and Recurrent Implantation Failure: Implications for Pregnancy Success

RPL and RIF are challenges in reproductive medicine. The immune system plays a pivotal role in endometrial receptivity, successful implantation, and pregnancy complications. Immunological changes have been associated with RPL and RIF. Understanding immune dysregulation especially in NK and T cell su...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical medicine 2023-08, Vol.12 (17), p.5585
Main Authors: Braun, Anne-Sophie, Vomstein, Kilian, Reiser, Elisabeth, Tollinger, Susanne, Kyvelidou, Christiana, Feil, Katharina, Toth, Bettina
Format: Article
Language:English
Subjects:
Antibiotics
Antibodies
Anticoagulants
B cells
Biopsy
Blood
Clinical medicine
Cytotoxicity
Dendritic cells
Drug dosages
Embryos
Endometrium
Ethylenediaminetetraacetic acid
Health aspects
Identification and classification
Immunology
Immunotherapy
Infertility, Female
Killer cells
Lymphocytes
Metronidazole
Miscarriage
Preeclampsia
Pregnancy
Pregnant women
Reproductive health
Risk factors
T cells
Vagina
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:RPL and RIF are challenges in reproductive medicine. The immune system plays a pivotal role in endometrial receptivity, successful implantation, and pregnancy complications. Immunological changes have been associated with RPL and RIF. Understanding immune dysregulation especially in NK and T cell subtypes may lead to better diagnostic concepts and treatments. From July 2019 to August 2020 patients with RPL and RIF underwent a standardized diagnostic procedure including endometrial biopsies. Immune cell analysis was performed using flow cytometry. Patients were contacted in March 2023 and interviewed concerning their pregnancy outcomes following diagnostics. Out of 68 patients undergoing endometrial biopsies, 49 patients were finally included. Live birth rates were high with 72% in RPL and 86% in RIF. Immune cell analysis revealed that patients with RPL had more cytotoxic CD56 CD16 cells, while RIF patients had more CD56 uNK cells. RPL patients with pregnancy complications showed increased NKT cell percentages. Our findings suggest specific immune changes in RPL and RIF patients, offering potential therapeutic targets. Tailored immunotherapy based on endometrial immunophenotyping might be an option, but further research is needed.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12175585