Unlocking therapeutic potential: integration of drug repurposing and immunotherapy for various disease targeting

• Published in: American journal of translational research 2023-01, Vol.15 (8), p.4984-5006
• Main Authors: Pawar, Vishakha Anand, Tyagi, Anuradha, Verma, Chaitenya, Sharma, Kanti Prakash, Ansari, Sekhu, Mani, Indra, Srivastva, Shailesh Kumar, Shukla, Pradeep Kumar, Kumar, Antresh, Kumar, Vinay
• Format: Article
• Language: English
• Subjects: Review
• ISSN: 1943-8141; 1943-8141

Drug repurposing, also known as drug repositioning, entails the application of pre-approved or formerly assessed drugs having potentially functional therapeutic amalgams for curing various disorders or disease conditions distinctive from their original remedial indication. It has surfaced as a substitute for the development of drugs for treating cancer, cardiovascular diseases, neurodegenerative disorders, and various infectious diseases like Covid-19. Although the earlier lines of findings in this area were serendipitous, recent advancements are based on patient centered approaches following systematic, translational, drug targeting practices that explore pathophysiological ailment mechanisms. The presence of definite information and numerous records with respect to beneficial properties, harmfulness, and pharmacologic characteristics of repurposed drugs increase the chances of approval in the clinical trial stages. The last few years have showcased the successful emergence of repurposed drug immunotherapy in treating various diseases. In this light, the present review emphasises on incorporation of drug repositioning with Immunotherapy targeted for several disorders.