Evaluation of drug carrier hepatotoxicity using primary cell culture models

This study aims to establish a primary rat hepatocyte culture model to evaluate dose-dependent hepatotoxic effects of drug carriers (lipopolymer nanoparticles; LPNs) temporal. Primary rat hepatocyte cell cultures were used to determine half-maximal Inhibition Concentrations (IC50) of the drug-carrie...

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Bibliographic Details
Published in:Nanomedicine 2023-02, Vol.48, p.102651-102651, Article 102651
Main Authors: Kibar, Güneş, Dutta, Subhadeep, Rege, Kaushal, Usta, O. Berk
Format: Article
Language:English
Subjects:
Albumins
Animals
Cells, Cultured
Chemical and Drug Induced Liver Injury - metabolism
Drug Carriers - pharmacology
Hepatocytes
Hepatotoxicity
In vitro culture
Lipopolymer nanoparticle (LPN)
Nanotoxicity
Primary Cell Culture
Primary rat hepatocyte
Rats
Urea - metabolism
Urea - pharmacology
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Summary:This study aims to establish a primary rat hepatocyte culture model to evaluate dose-dependent hepatotoxic effects of drug carriers (lipopolymer nanoparticles; LPNs) temporal. Primary rat hepatocyte cell cultures were used to determine half-maximal Inhibition Concentrations (IC50) of the drug-carrier library. Drug-carrier library, at concentrations
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2023.102651