Diagnostic value of high-frequency ultrasound (HFUS) in evaluation of subcutaneous lesions

It is unknown whether high-frequency ultrasound (HFUS) can evaluate invisible subcutaneous lesions. We aimed to investigate the diagnostic value of HFUS in invisible subcutaneous lesions. Patients with invisible subcutaneous lesions were prospectively recruited from two centres. Before undergoing bi...

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Published in:Skin research and technology 2023-09, Vol.29 (9), p.e13464
Main Authors: Miao, Yao, Ren, Wei-Wei, Yang, Fei-Yue, Li, Liang, Wu, Ling, Dan Shan, Dan, Chen, Zi-Tong, Wang, Li-Fan, Wang, Qiao, Guo, Le-Hang
Format: Article
Language:English
Subjects:
Accuracy
Biopsy
Cysts
Dermatofibrosarcoma protuberans
Diagnosis
Diagnostic systems
Epidermal Cyst - diagnostic imaging
Fibroids
Hair Diseases
Hemangioma
Hemangioma - diagnostic imaging
Histiocytoma, Benign Fibrous
Humans
Leiomyoma
Lesions
Lipoma
Neurofibroma
Original
Patients
Pilomatrixoma
Skin Neoplasms - diagnostic imaging
Ultrasonic imaging
Ultrasound
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cited_by cdi_FETCH-LOGICAL-c404t-fb81fc54920229f1e815322abdc30341c7cbbc19569ed089f1cecc3035d77d093
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container_issue 9
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container_title Skin research and technology
container_volume 29
creator Miao, Yao
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Yang, Fei-Yue
Li, Liang
Wu, Ling
Dan Shan, Dan
Chen, Zi-Tong
Wang, Li-Fan
Wang, Qiao
Guo, Le-Hang
description It is unknown whether high-frequency ultrasound (HFUS) can evaluate invisible subcutaneous lesions. We aimed to investigate the diagnostic value of HFUS in invisible subcutaneous lesions. Patients with invisible subcutaneous lesions were prospectively recruited from two centres. Before undergoing biopsy or surgery, each lesion was independently evaluated by two clinicians. One provides a clinical diagnosis by only clinical examination and the other provides an integrated diagnosis by combining clinical examination and HFUS information. Diagnoses were classified as correct, wrong, and indeterminate. A total of 391 lesions from 355 patients were enrolled, including 225 epidermoid cysts, 77 lipomas, 25 pilomatrixomas, 21 haemangiomas, 19 dermatofibromas, 11 dermatofibrosarcoma protuberans (DFSP), 7 neurofibromas, and 6 leiomyomas. Using pathological results as the gold standard, diagnostic performance was compared. The number of correct diagnoses increased from 185 (47.3%) by clinical examination alone to 316 (80.8%) after the addition of HFUS (P 
doi_str_mv 10.1111/srt.13464
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We aimed to investigate the diagnostic value of HFUS in invisible subcutaneous lesions. Patients with invisible subcutaneous lesions were prospectively recruited from two centres. Before undergoing biopsy or surgery, each lesion was independently evaluated by two clinicians. One provides a clinical diagnosis by only clinical examination and the other provides an integrated diagnosis by combining clinical examination and HFUS information. Diagnoses were classified as correct, wrong, and indeterminate. A total of 391 lesions from 355 patients were enrolled, including 225 epidermoid cysts, 77 lipomas, 25 pilomatrixomas, 21 haemangiomas, 19 dermatofibromas, 11 dermatofibrosarcoma protuberans (DFSP), 7 neurofibromas, and 6 leiomyomas. Using pathological results as the gold standard, diagnostic performance was compared. The number of correct diagnoses increased from 185 (47.3%) by clinical examination alone to 316 (80.8%) after the addition of HFUS (P &lt; 0.05). Meanwhile, the indeterminate diagnosis rate decreased from 143 (36.6%) to 10 (2.6%). Using HFUS, the accuracy improved significantly for epidermoid cysts (59.6% vs. 86.7%), lipomas (50.6% vs. 94.8%), pilomatrixomas (0% vs. 48.0%), haemangiomas (23.8% vs. 57.1%), and DFSPs (0% vs. 81.8%) (all p &lt; 0.05). However, HFUS did not significantly improve the diagnostic accuracy of dermatofibromas (15.8% vs. 21.1%, p &gt; 0.999), neurofibromas (42.9% vs. 71.4%, p = 0.625), or leiomyomas (16.7% vs. 100%, p = 0.063). Combining HFUS and clinical examination can generally improve the diagnostic accuracy and decrease the indeterminacy of invisible subcutaneous lesions, especially epidermoid cysts, lipomas, pilomatrixomas, haemangiomas, and DFSPs. 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We aimed to investigate the diagnostic value of HFUS in invisible subcutaneous lesions. Patients with invisible subcutaneous lesions were prospectively recruited from two centres. Before undergoing biopsy or surgery, each lesion was independently evaluated by two clinicians. One provides a clinical diagnosis by only clinical examination and the other provides an integrated diagnosis by combining clinical examination and HFUS information. Diagnoses were classified as correct, wrong, and indeterminate. A total of 391 lesions from 355 patients were enrolled, including 225 epidermoid cysts, 77 lipomas, 25 pilomatrixomas, 21 haemangiomas, 19 dermatofibromas, 11 dermatofibrosarcoma protuberans (DFSP), 7 neurofibromas, and 6 leiomyomas. Using pathological results as the gold standard, diagnostic performance was compared. The number of correct diagnoses increased from 185 (47.3%) by clinical examination alone to 316 (80.8%) after the addition of HFUS (P &lt; 0.05). 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We aimed to investigate the diagnostic value of HFUS in invisible subcutaneous lesions. Patients with invisible subcutaneous lesions were prospectively recruited from two centres. Before undergoing biopsy or surgery, each lesion was independently evaluated by two clinicians. One provides a clinical diagnosis by only clinical examination and the other provides an integrated diagnosis by combining clinical examination and HFUS information. Diagnoses were classified as correct, wrong, and indeterminate. A total of 391 lesions from 355 patients were enrolled, including 225 epidermoid cysts, 77 lipomas, 25 pilomatrixomas, 21 haemangiomas, 19 dermatofibromas, 11 dermatofibrosarcoma protuberans (DFSP), 7 neurofibromas, and 6 leiomyomas. Using pathological results as the gold standard, diagnostic performance was compared. The number of correct diagnoses increased from 185 (47.3%) by clinical examination alone to 316 (80.8%) after the addition of HFUS (P &lt; 0.05). Meanwhile, the indeterminate diagnosis rate decreased from 143 (36.6%) to 10 (2.6%). Using HFUS, the accuracy improved significantly for epidermoid cysts (59.6% vs. 86.7%), lipomas (50.6% vs. 94.8%), pilomatrixomas (0% vs. 48.0%), haemangiomas (23.8% vs. 57.1%), and DFSPs (0% vs. 81.8%) (all p &lt; 0.05). However, HFUS did not significantly improve the diagnostic accuracy of dermatofibromas (15.8% vs. 21.1%, p &gt; 0.999), neurofibromas (42.9% vs. 71.4%, p = 0.625), or leiomyomas (16.7% vs. 100%, p = 0.063). Combining HFUS and clinical examination can generally improve the diagnostic accuracy and decrease the indeterminacy of invisible subcutaneous lesions, especially epidermoid cysts, lipomas, pilomatrixomas, haemangiomas, and DFSPs. However, for some rare lesions, HFUS cannot provide useful information.</abstract><cop>England</cop><pub>John Wiley &amp; Sons, Inc</pub><pmid>37753674</pmid><doi>10.1111/srt.13464</doi><orcidid>https://orcid.org/0000-0002-5685-1280</orcidid><oa>free_for_read</oa></addata></record>
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subjects Accuracy
Biopsy
Cysts
Dermatofibrosarcoma protuberans
Diagnosis
Diagnostic systems
Epidermal Cyst - diagnostic imaging
Fibroids
Hair Diseases
Hemangioma
Hemangioma - diagnostic imaging
Histiocytoma, Benign Fibrous
Humans
Leiomyoma
Lesions
Lipoma
Neurofibroma
Original
Patients
Pilomatrixoma
Skin Neoplasms - diagnostic imaging
Ultrasonic imaging
Ultrasound
title Diagnostic value of high-frequency ultrasound (HFUS) in evaluation of subcutaneous lesions
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