Evaluation of renal disturbance in animal models of polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is an endocrine disease characterized by hyperandrogenism and hyperinsulinemia, followed by luteinizing hormone and follicle-stimulating hormone deficiency. PCOS conditions cause metabolic disorders that increase uric acid levels and malondialdehyde (MDA) levels. Ani...

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Bibliographic Details
Published in:Open Veterinary Journal 2023-08, Vol.13 (8), p.1003-1011
Main Authors: Oktanella, Yudit, Untari, Handayu, Wuragil, Dyah Kinasih, Ismiawati, Hana, Hasanah, Nur Afidatul, Agustina, Galuh Chandra, Pratama, Dyah Ayu Oktavianie
Format: Article
Language:English
Subjects:
animal model
Animals
Creatinine
estradiol valerate
Female
Kidney
Models, Animal
Original Research
pcos
Polycystic Ovary Syndrome - veterinary
Rats
Rats, Wistar
renal disturbance
testosterone propionate
Uric Acid
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Summary:Polycystic ovary syndrome (PCOS) is an endocrine disease characterized by hyperandrogenism and hyperinsulinemia, followed by luteinizing hormone and follicle-stimulating hormone deficiency. PCOS conditions cause metabolic disorders that increase uric acid levels and malondialdehyde (MDA) levels. Animal models of PCOS have been used extensively in research to study the pathogenesis, clinical characteristics, and treatment of PCOS. This study aimed to identify the pathological mechanisms underlying renal dysfunction in PCOS by observing several parameters, including blood urea nitrogen (BUN), creatinine, uric acid, and renal MDA levels. This research was an experimentally designed study using a Wistar rat ( ) as an animal model of PCOS which were divided into three groups: negative control group ( = 6), Testosterone propionate (TP) induction group ( = 6), and estradiol valerate (EV) induction group ( = 6). According to statistical analysis it indicated that induction of TP and EV can increase blood uric acid levels in PCOS model rats ( < 0.05), TP induction can increase kidney BUN and MDA levels significantly ( < 0.05), However, the observation of creatinine levels did not show significant differences in all treatment groups ( > 0.05). Based on the results of this study, it can be concluded that the induction of animal models with TP can trigger significant renal damage compared to EV.
ISSN:2226-4485
2218-6050
DOI:10.5455/OVJ.2023.v13.i8.6