Impact of Prefilled Syringes and Masking on Postintravitreal Injection Endophthalmitis

Purpose: To compare rates of endophthalmitis (1) following intravitreal injection of antivascular endothelial growth factor therapies with glass-vial preparation (GVP) vs prefilled syringes (PFS) and (2) before and after masking protocols were implemented. Methods: Medical records within a multicent...

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Published in:Journal of vitreoretinal diseases (Print) 2023-09, Vol.7 (5), p.382-388
Main Authors: Louis, Abigail M., Ali, Amna M., Patel, Sagar B., Fan, Kenneth C., Rahman, Effie Z., Pearce, William A., Trejo Corona, Stephanie, Villanueva Boone, Cecilia, Yu, Hannah J., Wykoff, Charles C.
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Language:English
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Summary:Purpose: To compare rates of endophthalmitis (1) following intravitreal injection of antivascular endothelial growth factor therapies with glass-vial preparation (GVP) vs prefilled syringes (PFS) and (2) before and after masking protocols were implemented. Methods: Medical records within a multicenter retina practice in Houston, Texas, from January 2015 to August 2021 were retrospectively reviewed. The primary outcome was rate of endophthalmitis after intravitreal injection. Results: A total of 307 349 injections were performed during the study period and 101 cases of endophthalmitis were identified (0.033%). PFS use was associated with a decreased risk of endophthalmitis (relative risk [RR], 0.320; 95% CI, 0.198-0.518, P 
ISSN:2474-1264
2474-1272
DOI:10.1177/24741264231191339