Early Development of Locomotion in the Term Piglet Model: Does Size Matter?

• Published in: Integrative and comparative biology 2023-09, Vol.63 (3), p.610-624
• Main Authors: Aerts, Peter, Mielke, Falk, Vanden Hole, Charlotte, Van Gorp, Merel J W, Van Ginneken, Chris
• Format: Article
• Language: English
• Subjects: Symposium
• ISSN: 1540-7063; 1557-7023; 1557-7023
• DOI: 10.1093/icb/icad054

Synopsis Intrauterine undernutrition in humans typically results in low birth weight ([small for gestational age] SGA) and delayed postnatal neuromotor maturation. Since SGA and intrauterine growth retardation are also common in domestic pigs, piglets are premised as models to study delayed motor development. Applied to the locomotor paradigm, however, questions emerge: (i) how to map the developmental time scale of the precocial model onto the altricial target species and (ii) how to distinguish size from maturation effects? Gait data were collected at self-selected voluntary walking speed during early development (0–96 hours postpartum; pp) for SGA- and normal ([appropriate for gestational age] AGA) piglets. Dimensionless spatiotemporal gait characteristics (according to dynamic similarity) become invariant already after 4 hours pp, suggesting rapid postnatal neuromotor maturation. Moreover, dimensionless gait data are largely identical for SGA- and AGA-siblings, indicating that primarily size effects explain absolute locomotor differences. This is further supported by (i) normalized force-generating capacity of limb muscles, (ii) joint kinematics (