Molecular docking analysis of a virulence factor protein dentilisin from Treponema denticola with oxazole piperazine derivatives

Dentilisin is a surface protease synthesized by the cell wall of Treponema denticola. This protein aids in the invasion of the periodontal tissue by causing infection. To identify drug molecules that have better results, homology modeling of the dentilisin protein was constructed, and molecular dock...

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Bibliographic Details
Published in:Bioinformation 2023-01, Vol.19 (1), p.57-62
Main Author: Parthiban, Kandeeban
Format: Article
Language:English
Online Access:Get full text
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Summary:Dentilisin is a surface protease synthesized by the cell wall of Treponema denticola. This protein aids in the invasion of the periodontal tissue by causing infection. To identify drug molecules that have better results, homology modeling of the dentilisin protein was constructed, and molecular docking was performed with the oxazole compounds (1-6) taken from previous studies that are not yet clinically used. Data shows that compounds 1, 2, 3 show better inhibiting properties.
ISSN:0973-8894
0973-2063
0973-2063
DOI:10.6026/97320630019057