Molecular docking analysis of thiazo inhibitors with the virulent factor cystalysin from Treponema denticola

has a virulent protein called cystalysin, which causes periodontitis. Therefore, it is of interest to design efficient drug that may have fewer side effects than the present clinical drugs, considering most of them are multidrug resistant. The molecular docking analysis show that the selected thiazo...

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Bibliographic Details
Published in:Bioinformation 2023-01, Vol.19 (1), p.94-98
Main Authors: Andrew, Serafina, Sankaran, Kavitha, Sekaran, Surya, Rengasamy, Gayathri, Veeraraghavan, Vishnu Priya, Eswaramoorthy, Rajalakshmanan
Format: Article
Language:English
Online Access:Get full text
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Summary:has a virulent protein called cystalysin, which causes periodontitis. Therefore, it is of interest to design efficient drug that may have fewer side effects than the present clinical drugs, considering most of them are multidrug resistant. The molecular docking analysis show that the selected thiazo derivatives (1-6) show better binding energies and amino acid interactions compared to the clinically proven drugs proving to be potential inhibitors against the protein.
ISSN:0973-2063
0973-8894
0973-2063
DOI:10.6026/97320630019094