Molecular docking analysis of Indole based oxadiazoles with the H-binding protein from Treponema denticola

Treponema denticola is a gram-negative bacteria that is associated with periodontal diseases. Literature derived, six indole based oxadiazole derivatives are docked with the target Factor H binding protein (fHbp) protein. Results show better docking interaction compared to clinically proven drugs an...

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Bibliographic Details
Published in:Bioinformation 2023-01, Vol.19 (1), p.79-84
Main Authors: Kumaran, Poojitha, Rengasamy, Gayathri, Sekaran, Surya, Sankaran, Kavitha, Veeraraghavan, Vishnu Priya, Eswaramoorthy, Rajalakshmanan
Format: Article
Language:English
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Summary:Treponema denticola is a gram-negative bacteria that is associated with periodontal diseases. Literature derived, six indole based oxadiazole derivatives are docked with the target Factor H binding protein (fHbp) protein. Results show better docking interaction compared to clinically proven drugs and all compounds obey Lipinski's rule of five. Hence, the compounds were inferred to be potential inhibitors for factor H binding protein of Treponema denticola .
ISSN:0973-2063
0973-8894
0973-2063
DOI:10.6026/97320630019079