Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds

Beta arrestins are a family of adaptor proteins that help in the regulation of signaling and trafficking of various G protein coupled receptors (GPCRs). Six oxadiazole derivatives taken from literature are analyzed for anti-cancer properties. The toxicity profiles of all the drugs were similar to Ta...

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Bibliographic Details
Published in:Bioinformation 2023-01, Vol.19 (1), p.111-116
Main Author: Sharma, Vipra
Format: Article
Language:English
Online Access:Get full text
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Summary:Beta arrestins are a family of adaptor proteins that help in the regulation of signaling and trafficking of various G protein coupled receptors (GPCRs). Six oxadiazole derivatives taken from literature are analyzed for anti-cancer properties. The toxicity profiles of all the drugs were similar to Tamoxifen used as control. Data shows that compounds 2, 4, and 6 exhibited comparably significant molecular interactions with the cancerous protein for further consideration.
ISSN:0973-8894
0973-2063
0973-2063
DOI:10.6026/97320630019111