Molecular docking analysis of oxazole compounds with the heme-binding protein from Porphyromonas gingivalis

Porphyromonas gingivalis, a peripathogen, has several methods to impede or modify the protective mechanisms of the teeth. Targeting the inhibition of the heme protein will prevent the organism from multiplying and inhibit the virulence mechanism. The literature derived oxazole compounds (1-5) were d...

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Bibliographic Details
Published in:Bioinformation 2023-01, Vol.19 (1), p.105-110
Main Author: Manikandan, Pranaw
Format: Article
Language:English
Online Access:Get full text
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Summary:Porphyromonas gingivalis, a peripathogen, has several methods to impede or modify the protective mechanisms of the teeth. Targeting the inhibition of the heme protein will prevent the organism from multiplying and inhibit the virulence mechanism. The literature derived oxazole compounds (1-5) were docked against the protein's active site, and the results show that the selected oxazole derivatives exhibit better interaction compared to clinically proven drugs.
ISSN:0973-8894
0973-2063
0973-2063
DOI:10.6026/97320630019105