Decisional Regret in Long-Term Australian Allogeneic Hematopoietic Stem Cell Transplantation Survivors: A Cross-Sectional Survey

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an intensive but effective treatment for malignant and non-malignant diseases. However, long-term survival often comes at a cost, with survivors experiencing chronic morbidity and are at risk of relapse and secondary malignancy. This...

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Published in:Clinical nursing research 2023-11, Vol.32 (8), p.1134-1144
Main Authors: McErlean, Gemma, Tapp, Caley, Brice, Lisa, Pradhan, Anisha, Gilroy, Nicole, Kabir, Masura, Greenwood, Matt, Larsen, Stephen R, Moore, John, Gottlieb, David, Hertzberg, Mark, Brown, Louisa, Hogg, Megan, Huang, Gillian, Ward, Christopher, Kerridge, Ian
Format: Article
Language:English
Subjects:
Clinical variables
Cross-sectional studies
Health care
Informed consent
Long term
Malignant
Medical personnel
Morbidity
Nurses
Polls & surveys
Postoperative Theme Section
Quality of life
Regret
Relapse
Socioeconomic factors
Stem cell transplantation
Stem cells
Survivor
Transplants
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Summary:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an intensive but effective treatment for malignant and non-malignant diseases. However, long-term survival often comes at a cost, with survivors experiencing chronic morbidity and are at risk of relapse and secondary malignancy. This study aimed to describe decisional regret in a large cohort of Australian long-term allo-HSCT survivors. A cross-sectional survey was conducted with 441 adults in New South Wales, assessing quality of life (QoL), psychological, social, demographic, and clinical variables. Less than 10% of survivors expressed regret, with chronic graft-versus-host disease being the most important clinical factor. Psycho-socioeconomic factors such as depression, lower QoL scores, lower household income, higher treatment burden, and not resuming sex post-HSCT were also associated with regret. Findings highlight the need for valid informed consent and ongoing follow-up and support for allo-HSCT survivors dealing with life post-transplant. Nurses and healthcare professionals play a critical role in addressing decisional regret in these patients.
ISSN:1054-7738
1552-3799
1552-3799
DOI:10.1177/10547738231180337