Metastatic Gastric Mucosal Melanoma: A Rare Case Presenting With Diffuse Gastric Polyposis

We report a 66-year-old Chinese lady who presented with a three-month history of postprandial vomiting, early satiety, anorexia and weight loss, and significant physical findings of hepatomegaly and ascites. Gastroscopy revealed gastric polyposis with both hyperpigmented and unpigmented lesions over...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-08, Vol.15 (8)
Main Authors: Yan, Zhi Hao, Huang, Jingxiang, Chiang, Jianbang, Kwan, Kah Wai Clarence
Format: Article
Language:English
Subjects:
Abdomen
Ascites
Case reports
Chemokines
Colon
Colonoscopy
Cysts
Edema
Esophagus
Gastroenterology
Immunotherapy
Ligands
Liver
Melanoma
Metastasis
Mutation
Oncology
Pathology
Polyps
Skin cancer
Small intestine
Stomach
Thrombocytopenia
Tomography
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Summary:We report a 66-year-old Chinese lady who presented with a three-month history of postprandial vomiting, early satiety, anorexia and weight loss, and significant physical findings of hepatomegaly and ascites. Gastroscopy revealed gastric polyposis with both hyperpigmented and unpigmented lesions over the gastric fundus, body, and proximal antrum, biopsies of which yielded malignant melanoma histologically. Cross-sectional imaging with CT also demonstrated extensive hepatic and bony metastases. No cutaneous or ocular primary was detected. She was treated with a combination of ipilimumab and nivolumab but developed interval progression of hepatic metastases after two cycles of immunotherapy. The patient eventually succumbed two months after diagnosis.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.43740