A Complicated Case of Aspirin-Exacerbated Respiratory Disease With Kounis Syndrome

Kounis syndrome is angina or acute coronary syndrome caused by mast cell degranulation and inflammatory cell activation. We present a case of a patient with underlying aspirin-exacerbated respiratory disease (AERD) and previous anaphylaxis to aspirin. The patient underwent aspirin desensitization an...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-09, Vol.15 (9)
Main Authors: Shaw, Krista M, Neaves, Brittanie I, Springer, Hayden A, Coop, Christopher A
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Allergies
Allergy/Immunology
Anaphylaxis
Angina pectoris
Aspirin
Asthma
Cardiac arrhythmia
Cardiac catheterization
Cardiology
Case reports
Coronary vessels
Heart attacks
Histamine
Immunology
Intubation
Military deployment
Pathophysiology
Patients
Polyps
Respiratory diseases
Thrombosis
Veins & arteries
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Description
Summary:Kounis syndrome is angina or acute coronary syndrome caused by mast cell degranulation and inflammatory cell activation. We present a case of a patient with underlying aspirin-exacerbated respiratory disease (AERD) and previous anaphylaxis to aspirin. The patient underwent aspirin desensitization and was then treated with high-dose aspirin. Unfortunately, he developed recurrent angina and myocardial infarction (MI). Numerous left heart catheterizations revealed vasospasms as the etiology of his MIs; however, therapy with increasing doses of vasodilators yielded no improvement in the patient’s condition. Ultimately the patient’s aspirin was discontinued and he had no recurrence of angina or MI.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.45635