The combination of non-contrast abbreviated MRI and alpha foetoprotein has high performance for hepatocellular carcinoma screening

Objectives This study aimed to compare two abbreviated MRI (AMRI) protocols to complete MRI for HCC detection: non-contrast (NC)-AMRI without/with alpha foetoprotein (AFP) and dynamic contrast-enhanced (Dyn)-AMRI. Methods This retrospective single-center study included 351 patients (M/F: 264/87, mea...

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Published in:European radiology 2023-10, Vol.33 (10), p.6929-6938
Main Authors: Girardet, Raphaël, Dubois, Margaux, Manasseh, Gibran, Jreige, Mario, Du Pasquier, Céline, Canniff, Emma, Gulizia, Marianna, Bonvin, Melissa, Aleman, Yasser, Taouli, Bachir, Fraga, Montserrat, Dromain, Clarisse, Vietti Violi, Naik
Format: Article
Language:English
Subjects:
alpha-Fetoproteins
Carcinoma, Hepatocellular - diagnostic imaging
Contrast agents
Contrast media
Contrast Media - pharmacology
Diagnostic Radiology
Diagnostic systems
Gadolinium
Gadolinium DTPA
Hepatocellular carcinoma
Humans
Imaging
Internal Medicine
Interventional Radiology
Liver cancer
Liver diseases
Liver Neoplasms - diagnostic imaging
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Original Article
Patients
Radiology
Retrospective Studies
Review
Sensitivity
Sensitivity and Specificity
Ultrasound
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Summary:Objectives This study aimed to compare two abbreviated MRI (AMRI) protocols to complete MRI for HCC detection: non-contrast (NC)-AMRI without/with alpha foetoprotein (AFP) and dynamic contrast-enhanced (Dyn)-AMRI. Methods This retrospective single-center study included 351 patients (M/F: 264/87, mean age: 57y) with chronic liver disease, who underwent MRI for HCC surveillance between 2014 and 2020. Two reconstructed AMRI sets were obtained based on complete MRI: NC-AMRI (T2-weighted imaging (WI) + diffusion-WI) and Dyn-AMRI (T2-WI + dynamic T1-WI) and were assessed by 2 radiologists who reported all suspicious lesions, using LI-RADS/adapted LI-RADS classification. The reference standard was based on all available patient data. Inter-reader agreement was assessed and MRI diagnostic performance was compared to the reference standard. Results The reference standard demonstrated 83/351 HCC-positive patients (prevalence: 23.6%, median size: 22 mm, and positive MRIs: 83/631). Inter-reader agreement was substantial for all sets. Sensitivities of Dyn-AMRI and complete MRI (both 92.8%) were similar, higher than NC-AMRI (72.3%, p  
ISSN:1432-1084
0938-7994
1432-1084
DOI:10.1007/s00330-023-09906-4