Controlled Structuring of Hyaluronan Films by Phase Separation and Inversion

This work explores application of phase separation phenomena for structuring of films made from hyaluronan. A time-sequenced dispensing of different solution mixtures was applied under rotation of hyaluronan-covered substrates to generate surface textures. This method is applicable in direct surface...

Full description

Saved in:
Bibliographic Details
Published in:Langmuir 2023-09, Vol.39 (37), p.13140-13148
Main Authors: Smolka, Petr, Kadlečková, Markéta, Kocourková, Karolína, Bartoňová, Martina, Mikulka, Filip, Knechtová, Eliška, Mráček, Aleš, Musilová, Lenka, Humenik, Martin, Minařík, Antonín
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This work explores application of phase separation phenomena for structuring of films made from hyaluronan. A time-sequenced dispensing of different solution mixtures was applied under rotation of hyaluronan-covered substrates to generate surface textures. This method is applicable in direct surface modification or cover layer deposition. Changes in the surface topography were characterized by atomic force microscopy, optical microscopy, and contact and non-contact profilometry. The mechanical properties of the surface-modified self-supporting films were compared using a universal testing machine. Experimental results show that diverse hyaluronan-based surface reliefs and self-supporting films with improved mechanical properties can be prepared using a newly designed multi-step phase separation process without the need for sacrificial removable templates or additives.
ISSN:0743-7463
1520-5827
DOI:10.1021/acs.langmuir.3c01547