Thyroid cancer pathologic upstaging: Frequency and related factors

Histopathologic assessment of thyroid tumors can lead to stage migration. We assessed frequency of pathologic upstaging, and associations with patient and tumor factors. Primary thyroid cancers treated between 2013 and 2015 were included from our institutional cancer registry. For tumor, nodal, and...

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Bibliographic Details
Published in:The American journal of surgery 2023-08, Vol.226 (2), p.171-175
Main Authors: Soegaard Ballester, Jacqueline M., Finn, Caitlin B., Ginzberg, Sara P., Kelz, Rachel R., Wachtel, Heather
Format: Article
Language:English
Subjects:
Age
Cancer
Cancer staging
Counseling
Histology
Histopathology
Humans
Lung Neoplasms - pathology
Lymphatic system
Metastasis
Neoplasm Staging
Patients
Pneumonectomy
Regression analysis
Stage migration
Thyroid
Thyroid cancer
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy
Tumors
Upstaging
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Summary:Histopathologic assessment of thyroid tumors can lead to stage migration. We assessed frequency of pathologic upstaging, and associations with patient and tumor factors. Primary thyroid cancers treated between 2013 and 2015 were included from our institutional cancer registry. For tumor, nodal, and summary stage, upstaging was present when final pathologic stage was greater than clinical staging. Multivariate logistic regression and Chi-squared tests were performed. 5,351 resected thyroid tumors were identified. Upstaging rates for tumor, nodal, and summary stage were 17.5% (n = 553/3156), 18.0% (n = 488/2705), and 10.9% (n = 285/2607), respectively. Age, Asian race, days to surgery, lymphovascular invasion, and follicular histology were significantly associated. Upstaging was significantly more common after total vs partial thyroidectomy, for tumor (19.4% vs 6.2%, p 
ISSN:0002-9610
1879-1883
1879-1883
DOI:10.1016/j.amjsurg.2023.03.023