A Rare Case of Acquired Factor VIII Deficiency in an Elderly Male With a History of Rheumatoid Arthritis

Acquired hemophilia A (AHA) or factor VIII (FVIII) deficiency is caused by autoantibodies targeting FVIII in the blood coagulation pathway; it is a rare condition making it challenging to diagnose. A timely diagnosis is crucial, without which there is a risk of catastrophic bleeding. We report a cas...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-08, Vol.15 (8)
Main Authors: Shah, Shubhangi, Tseng, Michael, Durojaiye, Ashimiyu
Format: Article
Language:English
Subjects:
Anemia
Anticoagulants
Cardiovascular disease
Case reports
Coronary vessels
Hematology
Hematoma
Hemophilia
Hemorrhage
Immunotherapy
Internal Medicine
Medical diagnosis
Monoclonal antibodies
Proteins
Rheumatoid arthritis
Rheumatology
Small intestine
Vein & artery diseases
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Summary:Acquired hemophilia A (AHA) or factor VIII (FVIII) deficiency is caused by autoantibodies targeting FVIII in the blood coagulation pathway; it is a rare condition making it challenging to diagnose. A timely diagnosis is crucial, without which there is a risk of catastrophic bleeding. We report a case of a patient with a history of duodenal arteriovenous malformations, previously on apixaban, who presented with four days of melena. On admission he was found to have a hemoglobin of 5.7 and elevated partial thromboplastin time (PTT), promoting further workup showing FVIII levels of
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.44169